Poulsen P, Vaag A, Beck-Nielsen H
Department of Endocrinology and Internal Medicine, Odense University Hospital, DK-5000 C Odense, Denmark.
BMJ. 1999 Jul 17;319(7203):151-4. doi: 10.1136/bmj.319.7203.151.
To study the influence of zygosity on the metabolic variables involved in the pathophysiology of type 2 diabetes.
Population based cross sectional study.
Odense University Hospital, Denmark.
125 monozygotic twin pairs and 178 dizygotic twin pairs of the same sex born between 1921 and 1940.
Clinical characteristics of monozygotic and dizygotic twins with or without a family history of type 2 diabetes.
Absolute prevalences of type 2 diabetes and impaired glucose tolerance according to the World Health Organisation criteria were similar in both the monozygotic and the dizygotic twins as were measurements of height, weight, body mass index, waist to hip ratio, and fasting plasma glucose and insulin concentrations. During the oral glucose tolerance test, monozygotic twins had a higher incremental plasma insulin area under the curve than dizygotic twins (10.05 (SD 0.68) v 9.89 (0.72) pmol/lxminutes, P<0.01) indicating insulin resistance. In twins with normal glucose tolerance and without first degree relatives or co-twins with type 2 diabetes or impaired glucose tolerance, both the glucose and insulin areas under the curve were higher among monozygotic twins (glucose 214.4 (88.3) v 189.8 (78.4) mmol/lxminutes, P<0.05; insulin 20 040 (14 865-32 554) v 17 625 (12 330-23 640) pmol/lxminutes, P=0.08).
Zygosity influences both plasma glucose and plasma insulin concentrations during an oral glucose tolerance test. This supports an intrauterine influence on glucose homeostasis and perhaps on insulin resistance in humans.
研究合子性对2型糖尿病病理生理学中涉及的代谢变量的影响。
基于人群的横断面研究。
丹麦欧登塞大学医院。
1921年至1940年间出生的125对同卵双胞胎和178对同性异卵双胞胎。
有无2型糖尿病家族史的同卵和异卵双胞胎的临床特征。
根据世界卫生组织标准，同卵和异卵双胞胎中2型糖尿病和糖耐量受损的绝对患病率相似，身高、体重、体重指数、腰臀比、空腹血糖和胰岛素浓度的测量结果也相似。在口服葡萄糖耐量试验期间，同卵双胞胎的血浆胰岛素曲线下增量面积高于异卵双胞胎（10.05（标准差0.68）对9.89（0.72）pmol/l×分钟，P<0.01），表明存在胰岛素抵抗。在糖耐量正常且无一级亲属或双胞胎患有2型糖尿病或糖耐量受损的双胞胎中，同卵双胞胎的葡萄糖和胰岛素曲线下面积均较高（葡萄糖214.4（88.3）对189.8（78.4）mmol/l×分钟，P<0.05；胰岛素20040（14865 - 32554）对17625（12330 - 23640）pmol/l×分钟，P = 0.08）。
合子性在口服葡萄糖耐量试验期间会影响血浆葡萄糖和血浆胰岛素浓度。这支持了子宫内对人类葡萄糖稳态以及可能对胰岛素抵抗的影响。
