Browne M, Gregson P J
School of Engineering Sciences, Materials Group, University of Southampton, UK.
Biomaterials. 2000 Feb;21(4):385-92. doi: 10.1016/s0142-9612(99)00200-8.
The degree of metal ion dissolution from Ti-6Al-4V alloy hip replacement stems subjected to various mechanical and chemical surface pretreatments was analysed in vitro. High-dissolution rates were observed for nitric acid passivated samples that had been mechanically surface treated to increase the implant surface area. Significantly lower ion release levels were observed for mechanically treated samples which had been aged in de-ionised water. The application of an hydroxyapatite coating decreased the metal ion release from the nitric acid passivated samples (compared to the uncoated sample) and increased the metal ion dissolution from the aged samples. The dissolution behaviour of the samples is explained in terms of the diffusion processes occurring at the stem/solution interface and the morphological and chemical characteristics of the surface treated stems.
体外分析了经过各种机械和化学表面预处理的Ti-6Al-4V合金髋关节置换柄的金属离子溶解程度。对于经过机械表面处理以增加植入物表面积的硝酸钝化样品，观察到高溶解率。对于在去离子水中时效处理的机械处理样品，观察到离子释放水平显著降低。羟基磷灰石涂层的应用降低了硝酸钝化样品（与未涂层样品相比）的金属离子释放，并增加了时效处理样品的金属离子溶解。根据柄/溶液界面处发生的扩散过程以及表面处理柄的形态和化学特性来解释样品的溶解行为。
