• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Dolastatin 3 and two novel cyclic peptides from a palauan collection of Lyngbya majuscula.

作者信息

Mitchell S S, Faulkner D J, Rubins K, Bushman F D

机构信息

Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212, USA.

出版信息

J Nat Prod. 2000 Feb;63(2):279-82. doi: 10.1021/np990353f.

DOI:10.1021/np990353f
PMID:10691729
Abstract

A collection of Lyngbya majuscula from Palau contained the peptides dolastatin 3 (1), homodolastatin 3 (2), and kororamide (3), together with aplysiatoxin (4), debromoaplysiatoxin (5), and oscillatoxin A (6). The structures of the new peptides homodolastatin 3 (2) and kororamide (3) were determined by interpretation of spectroscopic data and chemical degradation.

摘要

相似文献

1
Dolastatin 3 and two novel cyclic peptides from a palauan collection of Lyngbya majuscula.
J Nat Prod. 2000 Feb;63(2):279-82. doi: 10.1021/np990353f.
2
Isolation of homodolastatin 16, a new cyclic depsipeptide from a Kenyan collection of Lyngbya majuscula.从肯尼亚采集的巨大鞘丝藻中分离出新型环缩肽同型多拉司他汀16。
J Nat Prod. 2003 May;66(5):712-5. doi: 10.1021/np030014t.
3
Somamides A and B, two new depsipeptide analogues of dolastatin 13 from a Fijian cyanobacterial assemblage of Lyngbya majuscula and Schizothrix species.索马米德A和B，两种来自斐济大型鞘丝藻和裂须藻蓝藻组合的新型缩肽类多拉司他汀13类似物。
J Nat Prod. 2001 Jun;64(6):716-9. doi: 10.1021/np000634j.
4
Isolation of four new cyclic depsipeptides, antanapeptins A-D, and dolastatin 16 from a Madagascan collection of Lyngbya majuscula.从马达加斯加采集的巨大鞘丝藻中分离出四种新的环缩肽——安塔那肽A-D以及多拉司他汀16。
J Nat Prod. 2002 Jan;65(1):21-4. doi: 10.1021/np010348n.
5
Isolation and structure determination of lyngbyastatin 3, a lyngbyastatin 1 homologue from the marine cyanobacterium Lyngbya majuscula. Determination of the configuration of the 4-amino-2,2-dimethyl-3-oxopentanoic acid unit in majusculamide C, dolastatin 12, lyngbyastatin 1, and lyngbyastatin 3 from cyanobacteria.从海洋蓝藻巨大鞘丝藻中分离出林比他汀3（一种林比他汀1的同系物）并确定其结构。确定来自蓝藻的马朱斯库酰胺C、多拉司他汀12、林比他汀1和林比他汀3中4-氨基-2,2-二甲基-3-氧代戊酸单元的构型。
J Nat Prod. 2003 Oct;66(10):1356-63. doi: 10.1021/np0302145.
6
Ulongapeptin, a cytotoxic cyclic depsipeptide from a Palauan marine cyanobacterium Lyngbya sp.乌鲁那肽，一种从帕劳海洋蓝藻鞘丝藻属（Lyngbya sp.）中提取的具有细胞毒性的环缩肽。
J Nat Prod. 2003 May;66(5):651-4. doi: 10.1021/np030050s.
7
Isolation, structure determination, and biological activity of Lyngbyabellin A from the marine cyanobacterium lyngbya majuscula.从海洋蓝藻巨大鞘丝藻中分离、确定结构及研究林格比藻毒素A的生物活性。
J Nat Prod. 2000 May;63(5):611-5. doi: 10.1021/np990543q.
8
Lyngbyastatin 2 and norlyngbyastatin 2, analogues of dolastatin G and nordolastatin G from the marine cyanobacterium Lyngbya majuscula.灵比他汀2和去甲灵比他汀2，是来自海洋蓝藻巨大鞘丝藻的多拉他汀G和去甲多拉他汀G的类似物。
J Nat Prod. 1999 Dec;62(12):1702-6. doi: 10.1021/np990310z.
9
Yanucamides A and B, two new depsipeptides from an assemblage of the marine cyanobacteria Lyngbya majuscula and Schizothrix species.雅努卡酰胺A和B，从海洋蓝藻巨大鞘丝藻和裂须藻组合中分离出的两种新型缩肽。
J Nat Prod. 2000 Feb;63(2):197-200. doi: 10.1021/np990466z.
10
Pitipeptolides A and B, new cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula.皮提肽A和B，来自海洋蓝藻大鞘丝藻的新型环缩肽。
J Nat Prod. 2001 Mar;64(3):304-7. doi: 10.1021/np000456u.

引用本文的文献

1
Marine Cyanobacteria: A Rich Source of Structurally Unique Anti-Infectives for Drug Development.海洋蓝细菌：用于药物开发的结构独特抗感染药物的丰富来源。
Molecules. 2024 Nov 10;29(22):5307. doi: 10.3390/molecules29225307.
2
The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987-2020).海洋微生物含硫天然产物的有趣化学与生物学研究（1987 - 2020年）
Mar Life Sci Technol. 2021 May 19;3(4):488-518. doi: 10.1007/s42995-021-00101-2. eCollection 2021 Nov.
3
Cyanometabolites: molecules with immense antiviral potential.
氰基代谢物：具有巨大抗病毒潜力的分子。
Arch Microbiol. 2023 Apr 3;205(5):164. doi: 10.1007/s00203-023-03514-y.
4
Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides.核糖体合成和翻译后修饰肽的作用机制。
Chem Rev. 2022 Sep 28;122(18):14722-14814. doi: 10.1021/acs.chemrev.2c00210. Epub 2022 Sep 1.
5
Antiviral Peptides (AVPs) of Marine Origin as Propitious Therapeutic Drug Candidates for the Treatment of Human Viruses.海洋源抗病毒肽 (AVP) 作为治疗人类病毒的有前途的治疗药物候选物。
Molecules. 2022 Apr 19;27(9):2619. doi: 10.3390/molecules27092619.
6
Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis.源自大型藻类、微藻和蓝细菌的病毒抑制剂：对整个发病过程中抗病毒潜力的综述
Algal Res. 2021 Jul;57:102331. doi: 10.1016/j.algal.2021.102331. Epub 2021 May 18.
7
Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs).核糖体合成和翻译后修饰肽（RiPPs）的抗病毒活性及应用。
Cell Mol Life Sci. 2021 Apr;78(8):3921-3940. doi: 10.1007/s00018-021-03759-0. Epub 2021 Feb 2.
8
A Multi-Omics Characterization of the Natural Product Potential of Tropical Filamentous Marine Cyanobacteria.热带丝状海洋蓝细菌天然产物潜力的多组学特征分析。
Mar Drugs. 2021 Jan 6;19(1):20. doi: 10.3390/md19010020.
9
Bioactive Compounds from Marine Heterobranchs.海洋异齿类动物中的生物活性化合物。
Mar Drugs. 2020 Dec 21;18(12):657. doi: 10.3390/md18120657.
10
Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects.海洋资源中天然生物活性噻唑基肽：结构和药理学方面。
Mar Drugs. 2020 Jun 24;18(6):329. doi: 10.3390/md18060329.