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3-咪唑基甲基氨基苯基磺酰基四氢喹啉类化合物，一类新型的法尼基转移酶抑制剂

3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors.

作者信息

Ding C Z, Hunt J T, Ricca C, Manne V

机构信息

Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.

出版信息

Bioorg Med Chem Lett. 2000 Feb 7;10(3):273-5. doi: 10.1016/s0960-894x(99)00686-1.

DOI:10.1016/s0960-894x(99)00686-1
PMID:10698452
Abstract

Design, synthesis and structure-activity relationship of a series of 3-imidazolylmethylaminophenylsulfonyltetrahydroquinolines as farnesyltransferase inhibitors are presented. A working pharmacophore of inhibiting farnesyltransferase by this series of inhibitors is proposed.

摘要

本文介绍了一系列3-咪唑基甲基氨基苯基磺酰基四氢喹啉作为法尼基转移酶抑制剂的设计、合成及其构效关系。提出了该系列抑制剂抑制法尼基转移酶的有效药效团。

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