年龄相关性眼病研究：锌与抗氧化剂的临床试验——年龄相关性眼病研究报告第2号
The Age-Related Eye Disease Study: a clinical trial of zinc and antioxidants--Age-Related Eye Disease Study Report No. 2.
出版信息
J Nutr. 2000 May;130(5S Suppl):1516S-9S. doi: 10.1093/jn/130.5.1516S.
Abstract
The Age-Related Eye Disease Study includes a clinical trial of high dose antioxidant and zinc supplements for age-related macular degeneration and a clinical trial of high dose antioxidants for cataract. The clinical trials were initiated largely because of the widespread public use in the United States of commercially available pharmacological doses of vitamins and minerals to treat these two eye conditions and the absence of definitive studies on the safety and efficacy of their use. This report focuses on the clinical trial of zinc and the possibility that this elderly study cohort, who were randomly assigned in a factorial design to receive zinc, antioxidants and placebo, could be assessed for zinc effects other than those currently addressed by the trial.
摘要
年龄相关性眼病研究包括一项针对年龄相关性黄斑变性的高剂量抗氧化剂和锌补充剂的临床试验，以及一项针对白内障的高剂量抗氧化剂的临床试验。开展这些临床试验主要是因为在美国，商业销售的药理剂量的维生素和矿物质被广泛用于治疗这两种眼部疾病，而关于其使用安全性和有效性的确定性研究却付诸阙如。本报告聚焦于锌的临床试验，以及对这个老年研究队列进行评估的可能性，该队列在析因设计中被随机分配接受锌、抗氧化剂和安慰剂，以探究除该试验目前所涉及的锌的作用之外的其他作用。
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