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关于氨基糖苷类失活酶AAC-(6')IV的研究（作者译）

[Investigations on the aminoglycoside inactivating enzyme AAC-(6') IV (author's transl)].

作者信息

Wiedemann B, Klopfer-Kaul I, Tetzlaff G

出版信息

Infection. 1979;7 Suppl 2:S192-6. doi: 10.1007/BF01641122.

DOI:10.1007/BF01641122
PMID:108221
Abstract

In Serratia marcescens and Pseudomonas aeruginosa from clinical specimen acetyltransferase AAC-(6') IV leads to varying phaenotypically expressed resistance to aminoglycoside antibiotics. The substrate profile and the rate of inactivation of the enzymes investigated are almost identical with each other and with the enzyme of P. aeruginosa GN 315. The enzymes cannot be associated with R factors by the standard methods for conjugation, transformation, density gradient centrifugation and agarose gel electrophoresis.

摘要

在从临床标本中分离出的粘质沙雷氏菌和铜绿假单胞菌中，乙酰转移酶AAC-(6')IV导致对氨基糖苷类抗生素产生不同表型表达的耐药性。所研究酶的底物谱和失活速率彼此几乎相同，且与铜绿假单胞菌GN 315的酶相同。通过用于接合、转化、密度梯度离心和琼脂糖凝胶电泳的标准方法，这些酶不能与R因子相关联。

相似文献

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[Investigations on the aminoglycoside inactivating enzyme AAC-(6') IV (author's transl)].关于氨基糖苷类失活酶AAC-(6')IV的研究（作者译）
Infection. 1979;7 Suppl 2:S192-6. doi: 10.1007/BF01641122.
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Antibiot Khimioter. 1992 Nov;37(11):10-4.
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novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa.新型 6'-N-氨基糖苷乙酰转移酶 AAC(6')-Iaj 来自临床分离的铜绿假单胞菌。
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J Antimicrob Chemother. 1993 Jun;31(6):841-54. doi: 10.1093/jac/31.6.841.

引用本文的文献

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Evidence for a chromosomal site specifying amikacin resistance in multiresistant Serratia marcescens.多耐药性粘质沙雷氏菌中一个指定阿米卡星抗性的染色体位点的证据。
Antimicrob Agents Chemother. 1982 Apr;21(4):587-91. doi: 10.1128/AAC.21.4.587.

本文引用的文献

1
Non-chromosomal antibiotic resistance in bacteria. 3. Isolation of the discrete transfer unit of the R-factor R1.细菌中的非染色体抗生素抗性。3. R 因子 R1 离散转移单位的分离。
Proc Natl Acad Sci U S A. 1970 Oct;67(2):510-6. doi: 10.1073/pnas.67.2.510.
2
Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.携带R因子的大肠杆菌对氨基糖苷类抗生素的酶促乙酰化作用。
Biochemistry. 1971 May 11;10(10):1787-96. doi: 10.1021/bi00786a009.
3
Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form.
大肠杆菌中的超螺旋环状DNA-蛋白质复合物：纯化及诱导转化为开放环状DNA形式
Proc Natl Acad Sci U S A. 1969 Apr;62(4):1159-66. doi: 10.1073/pnas.62.4.1159.
4
Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli.由卡那霉素抗性大肠杆菌无细胞系统使卡那霉素失活后的分离及结构研究
J Antibiot (Tokyo). 1967 Jul;20(3):136-41.
5
6'-N-acetylation of 3',4'-dideoxykanamycin B by an enzyme in a resistant strain of Pseudomonas aeruginosa.铜绿假单胞菌耐药菌株中一种酶对3',4'-双脱氧卡那霉素B的6'-N-乙酰化作用
J Antibiot (Tokyo). 1972 Aug;25(8):495-6. doi: 10.7164/antibiotics.25.495.
6
Chromosome mapping in Pseudomonas aeruginosa.铜绿假单胞菌的染色体图谱分析
Genet Res. 1972 Jun;19(3):251-60. doi: 10.1017/s0016672300014518.
7
Properties of a R factor which originated in Pseudomonas aeruginosa 1822.源自铜绿假单胞菌1822的一种R因子的特性。
J Bacteriol. 1972 May;110(2):529-37. doi: 10.1128/jb.110.2.529-537.1972.
8
The release of enzymes by osmotic shock from Escherichia coli in exponential phase.处于对数期的大肠杆菌通过渗透休克释放酶。
J Biol Chem. 1966 Jul 10;241(13):3055-62.
9
Properties of an R plasmid in Pseudomonas aeruginosa producing amikacin (BB-K8), butirosin, kanamycin, tobramycin, and sisomicin resistance.铜绿假单胞菌中一种产生阿米卡星（BB-K8）、丁胺卡那霉素、卡那霉素、妥布霉素和西索米星抗性的R质粒的特性
Antimicrob Agents Chemother. 1974 Dec;6(6):807-10. doi: 10.1128/AAC.6.6.807.
10
Transferrable resistance to tobramycin in Klebsiella pneumoniae and Enterobacter cloacae associated with enzymatic acetylation of tobramycin.肺炎克雷伯菌和阴沟肠杆菌中与妥布霉素酶促乙酰化相关的可转移的妥布霉素耐药性。
Antimicrob Agents Chemother. 1974 Oct;6(4):492-7. doi: 10.1128/AAC.6.4.492.