辅助性T淋巴细胞与抑制性T淋巴细胞的分离。II. Ly表型以及伴刀豆球蛋白A辅助性和抑制性细胞生成对DNA合成需求的缺乏
Separation of helper and suppressor T lymphocytes. II. Ly phenotypes and lack of DNA synthesis requirement for the generation of concanavalin A helper and suppressor cells.
作者信息
Tse H Y, Dutton R W
出版信息
J Exp Med. 1977 Sep 1;146(3):747-58. doi: 10.1084/jem.146.3.747.
Abstract
Using a Ficoll velocity sedimentation gradient, we have been able to fractionate concanavalin A (Con A)-induced helper and suppressor cells into separate pools. Cells activated by Con A to mediate helper activity are Ly1+, do not require DNA synthesis for induction, and remain as small cells after activation. Suppressor cells are Ly23+, are found in the blast cell fraction and their induction is not inhibitable by prior treatment with mitomycin C or irradiation, both of which inhibit DNA synthesis. The implications of such findings are discussed.
摘要
利用Ficoll速度沉降梯度，我们已能够将伴刀豆球蛋白A（Con A）诱导的辅助性细胞和抑制性细胞分馏到不同的细胞群中。被Con A激活以介导辅助活性的细胞是Ly1 +，诱导过程不需要DNA合成，激活后仍为小细胞。抑制性细胞是Ly23 +，存在于母细胞组分中，其诱导不受丝裂霉素C预处理或照射的抑制，而丝裂霉素C和照射两者均抑制DNA合成。讨论了这些发现的意义。
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