Flegar-Mestrić Z, Nazor A, Jagarinec N
Institute of Clinical Chemistry, Clinical Hospital Merkur, Zagreb, Croatia.
Coll Antropol. 2000 Jun;24(1):185-96.
Haematological profile for 17 constituents of blood were determined in 998 healthy school children (8-19 years old) and 2246 healthy adult persons (20-70 years old) residing permanently or at least 5 years in a defined geographic region of Zagreb, Croatia. Physiological variations corresponding to age and sex were studied as the most important factors affecting biological variation in haematological constituents of blood. In our study erythrocytes, haemoglobin and haematocrit values were not sex dependent until the age of 13 after which the values were higher in men that in women. Sedimentation rate showed sex and age related differences in the adult age with higher values in women especially after 50 years. Total leukocyte count declined with age and in adults the values were slightly lower in women. Segmented neutrophil granulocytes showed the upward trend with age whereas the lymphocyte and monocyte counts declined. Women showed slightly higher platelet count in the adult age. Based on biological variation, we have estimated the reference intervals for 17 haematological constituents of blood in order to provide medically reliable evaluation of haematological laboratory results.
对居住在克罗地亚萨格勒布特定地理区域、永久居住或至少居住5年的998名健康学龄儿童（8至19岁）和2246名健康成年人（20至70岁）测定了血液中17种成分的血液学指标。研究了与年龄和性别相关的生理变异，将其作为影响血液学成分生物学变异的最重要因素。在我们的研究中，红细胞、血红蛋白和血细胞比容值在13岁之前不依赖于性别，13岁之后男性的值高于女性。血沉率在成年人中显示出与性别和年龄相关的差异，女性的值更高，尤其是50岁以后。总白细胞计数随年龄下降，在成年人中女性的值略低。分叶核中性粒细胞计数随年龄呈上升趋势，而淋巴细胞和单核细胞计数下降。成年女性的血小板计数略高。基于生物学变异，我们估计了血液中17种血液学成分的参考区间，以便为血液学实验室结果提供医学上可靠的评估。
