Ghebremeskel K, Min Y, Crawford M A, Nam J H, Kim A, Koo J N, Suzuki H
Institute of Brain Chemistry and Human Nutrition, The University of North London, United Kingdom.
Lipids. 2000 May;35(5):567-74. doi: 10.1007/s11745-000-557-3.
Relative fatty acid composition of plasma and red blood cell (RBC) choline phosphoglycerides (CPG), and RBC ethanolamine phosphoglycerides (EPG) of pregnant (n = 40) and nonpregnant, nonlactating (n = 40), healthy Korean women was compared. The two groups were of the same ethnic origin and comparable in age and parity. Levels of arachidonic (AA) and docosahexaenoic (DHA) acids were lower (P < 0.05) and palmitic and oleic acids higher (P < 0.0001) in plasma CPG of the pregnant women. Similarly, the RBC CPG and EPG of the pregnant women had lower AA and DHA (P < 0.05) and higher palmitic and oleic acids (P < 0.01). The reduction in DHA and total n-3 fatty acids in plasma CPG of the pregnant women was paralleled by an increase in docosatetraenoic (DTA) and docosapentaenoic (DPA) acids of the n-6 series and in DPA/DTA ratio. In the RBC phospholipids (CPG and EPG) of the pregnant women, DTA and DPA acids of the n-6 series and DPA/DTA ratio did not increase with the decrease of the n-3 metabolites (eicosapentaenoic acid, DPA, and DHA) and total n-3. Since pregnancy was the main identifiable variable between the two groups, the lower levels of AA and DHA in RBC CPG and EPG of the pregnant women suggest that the mothers were mobilizing membrane AA and DHA to meet the high fetal requirement for these nutrients. It may also suggest that RBC play a role as a potential store of AA and DHA and as a vehicle for the transport of these fatty acids from maternal circulation to the placenta to be utilized by the developing fetus.
对40名韩国孕妇及40名非孕、非哺乳期健康女性的血浆、红细胞（RBC）胆碱磷酸甘油酯（CPG）以及红细胞乙醇胺磷酸甘油酯（EPG）的相对脂肪酸组成进行了比较。两组女性种族相同，年龄和胎次相当。孕妇血浆CPG中的花生四烯酸（AA）和二十二碳六烯酸（DHA）水平较低（P<0.05），而棕榈酸和油酸水平较高（P<0.0001）。同样，孕妇的红细胞CPG和EPG中AA和DHA含量较低（P<0.05），棕榈酸和油酸含量较高（P<0.01）。孕妇血浆CPG中DHA和总n-3脂肪酸的减少伴随着n-6系列的二十二碳四烯酸（DTA）和二十二碳五烯酸（DPA）以及DPA/DTA比值的增加。在孕妇的红细胞磷脂（CPG和EPG）中，n-6系列的DTA和DPA以及DPA/DTA比值并未随着n-3代谢物（二十碳五烯酸、DPA和DHA）和总n-3的减少而增加。由于怀孕是两组之间主要的可识别变量，孕妇红细胞CPG和EPG中AA和DHA水平较低表明母亲正在动员膜内的AA和DHA以满足胎儿对这些营养素的高需求。这也可能表明红细胞作为AA和DHA的潜在储存库以及这些脂肪酸从母体循环转运至胎盘以供发育中的胎儿利用的载体发挥着作用。
