El-Dakhakhny M, Barakat M, El-Halim M A, Aly S M
Department of Pharmacology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
J Ethnopharmacol. 2000 Sep;72(1-2):299-304. doi: 10.1016/s0378-8741(00)00235-x.
The present work was done to investigate the possible effects of Nigella sativa oil (NSO) on gastric secretion and ethanol-induced ulcer in rats. Thirty two adult male rats were used in this study (four groups) and several parameters were determined to assess any degree of protection. It was found that the administration of NSO in rats produced a significant increase in mucin content and glutathione level and a significant decrease in mucosal histamine content. Ethanol administration produced a 100% ulcer induction with an ulcer score of 12.62+/-1.35 (mean+/-S.E., n=8). It caused a significant reduction in free acidity and glutathione level while it produced a significant increase in mucosal histamine content. When animals were pretreated with NSO before induction of ulcer, there was a significant increase in glutathione level, mucin content and free acidity and a significant decrease in gastric mucosal histamine content with a protection ratio of 53.56% as compared to the ethanol group. It can be concluded that NSO imparted a protective action against ethanol induced ulcer in rats.
本研究旨在探讨黑种草籽油（NSO）对大鼠胃分泌及乙醇诱导溃疡的可能影响。本研究使用了32只成年雄性大鼠（分为四组），并测定了几个参数以评估保护程度。结果发现，给大鼠服用NSO后，粘蛋白含量和谷胱甘肽水平显著增加，而粘膜组胺含量显著降低。给予乙醇导致100%的溃疡发生率，溃疡评分为12.62±1.35（平均值±标准误，n = 8）。它导致游离酸度和谷胱甘肽水平显著降低，同时粘膜组胺含量显著增加。当在诱导溃疡前用NSO预处理动物时，谷胱甘肽水平、粘蛋白含量和游离酸度显著增加，胃粘膜组胺含量显著降低，与乙醇组相比保护率为53.56%。可以得出结论，NSO对大鼠乙醇诱导的溃疡具有保护作用。
