奇异变形杆菌和斯氏普罗威登斯菌分离株产生的新型 TEM 变体（TEM-92）。
New TEM variant (TEM-92) produced by Proteus mirabilis and Providencia stuartii isolates.
作者信息
de Champs C, Monne C, Bonnet R, Sougakoff W, Sirot D, Chanal C, Sirot J
机构信息
Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex, France.
出版信息
Antimicrob Agents Chemother. 2001 Apr;45(4):1278-80. doi: 10.1128/AAC.45.4.1278-1280.2001.
Abstract
The sequences of the bla(TEM) genes encoding TEM-92 in Proteus mirabilis and Providencia stuartii isolates were determined and were found to be identical. Except for positions 218 (Lys-6) and 512 (Lys-104), the nucleotide sequence of bla(TEM-92) was identical to that of bla(TEM-20), including the sequence of the promoter region harboring a 135-bp deletion combined with a G-162-->T substitution. The deduced amino acid sequence of TEM-92 differed from that of TEM-52 by the presence of a substitution (Gln-6-->Lys) in the peptide signal.
摘要
测定了奇异变形杆菌和斯氏普罗威登斯菌分离株中编码TEM-92的bla(TEM)基因序列，发现它们是相同的。除了第218位（赖氨酸-6）和第512位（赖氨酸-104）外，bla(TEM-92)的核苷酸序列与bla(TEM-20)相同，包括含有135bp缺失并伴有G-162→T替换的启动子区域序列。TEM-92推导的氨基酸序列与TEM-52的不同之处在于肽信号中存在一个替换（谷氨酰胺-6→赖氨酸）。
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