Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen B K
Department of Infectious Diseases M7721, Rigshospitalet, 2200 KBH N, Denmark.
Eur J Appl Physiol. 2001 Mar;84(3):244-5. doi: 10.1007/s004210170012.
During the last few years much attention has been paid to the chemokines. Chemokine receptors are necessary to render a target permissive for infection by the human immunodeficiency virus (HIV) and high concentrations of chemokines have been shown to protect against the progression of HIV disease towards death. In the present study, we investigated the capability of strenuous exercise to induce elevated plasma concentrations of the chemokines interleukin (IL)-8, macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta. Eight male athletes completed the Copenhagen Marathon 1997. Blood was sampled before, immediately after the run and every 30 min during a 4 h recovery period. Plasma chemokine concentrations were measured using enzyme-linked immunosorbent assays. The IL-8, MIP-1 alpha and MIP-1 beta concentrations all peaked 0.5 h after the run when they were 6.7-fold, 3.5-fold and 4.1-fold increased, respectively. The elevated concentrations of chemokines in plasma after exercise could have implications for HIV-infected individuals; a possibility that needs further investigation.
在过去几年中，趋化因子受到了广泛关注。趋化因子受体是人类免疫缺陷病毒（HIV）感染靶细胞所必需的，并且已证明高浓度的趋化因子可预防HIV疾病发展至死亡。在本研究中，我们调查了剧烈运动诱导血浆趋化因子白细胞介素（IL）-8、巨噬细胞炎性蛋白（MIP）-1α和MIP-1β浓度升高的能力。八名男性运动员完成了1997年哥本哈根马拉松比赛。在跑步前、跑步结束后立即以及4小时恢复期内每隔30分钟采集血液样本。使用酶联免疫吸附测定法测量血浆趋化因子浓度。IL-8、MIP-1α和MIP-1β浓度在跑步后0.5小时均达到峰值，分别升高了6.7倍、3.5倍和4.1倍。运动后血浆中趋化因子浓度升高可能对HIV感染者有影响；这一可能性需要进一步研究。
