羧苄西林和替卡西林与庆大霉素的相互作用。
Interactions of carbenicillin and ticarcillin with gentamicin.
作者信息
Davies M, Morgan J R, Anand C
出版信息
Antimicrob Agents Chemother. 1975 Apr;7(4):431-4. doi: 10.1128/AAC.7.4.431.
Abstract
The in vitro inactivation of gentamicin by carbenicillin and a new semisynthetic penicillin, ticarcillin (BRL 2288), has been demonstrated. Gentamicin half-lives have been studied in eight patients with end-stage renal failure, and a 25 to 74% reduction in half-life has resulted from the concomitant administration of therapeutic doses of carbenicillin and ticarcillin.
摘要
已证实羧苄西林和一种新型半合成青霉素替卡西林（BRL 2288）可在体外使庆大霉素失活。对8例终末期肾衰竭患者的庆大霉素半衰期进行了研究，同时给予治疗剂量的羧苄西林和替卡西林导致半衰期降低了25%至74%。
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