Pedersen B K, Steensberg A, Schjerling P
The Copenhagen Muscle Research Centre, University of Copenhagen, Denmark.
J Physiol. 2001 Oct 15;536(Pt 2):329-37. doi: 10.1111/j.1469-7793.2001.0329c.xd.
Interleukin-6 (IL-6) is produced locally in working skeletal muscle and can account for the increase in plasma IL-6 during exercise. The production of IL-6 during exercise is related to the intensity and duration of the exercise, and low muscle glycogen content stimulates the production. Muscle-derived IL-6 is released into the circulation during exercise in high amounts and is likely to work in a hormone-like fashion, exerting an effect on the liver and adipose tissue, thereby contributing to the maintenance of glucose homeostasis during exercise and mediating exercise-induced lipolysis. Muscle-derived IL-6 may also work to inhibit the effects of pro-inflammatory cytokines such as tumour necrosis factor alpha. The latter cytokine is produced by adipose tissue and inflammatory cells and appears to play a pathogenetic role in insulin resistance and atherogenesis.
白细胞介素-6（IL-6）在运动的骨骼肌局部产生，可解释运动期间血浆IL-6的增加。运动期间IL-6的产生与运动强度和持续时间有关，低肌肉糖原含量会刺激其产生。运动期间，肌肉来源的IL-6大量释放到循环中，可能以类似激素的方式发挥作用，对肝脏和脂肪组织产生影响，从而有助于运动期间维持葡萄糖稳态并介导运动诱导的脂肪分解。肌肉来源的IL-6也可能发挥作用，抑制促炎细胞因子如肿瘤坏死因子α的作用。后一种细胞因子由脂肪组织和炎症细胞产生，似乎在胰岛素抵抗和动脉粥样硬化的发病机制中起作用。
