产 TEM 衍生物的产气肠杆菌菌株：一种流行克隆的传播
TEM derivative-producing Enterobacter aerogenes strains: dissemination of a prevalent clone.
作者信息
Dumarche P, De Champs C, Sirot D, Chanal C, Bonnet R, Sirot J
机构信息
Faculté de Médecine, Laboratoire de Bactériologie, 63001 Clermont-Ferrand Cedex, France.
出版信息
Antimicrob Agents Chemother. 2002 Apr;46(4):1128-31. doi: 10.1128/AAC.46.4.1128-1131.2002.
Abstract
TEM-24 (CAZ-6) extended-spectrum beta-lactamase (ESBL) was detected in 1988 in Clermont-Ferrand, France, in Klebsiella pneumoniae (bla(TEM-24)) and Enterobacter aerogenes (bla(TEM-24b)), and since 1994, a TEM-24-producing E. aerogenes clonal strain has been observed elsewhere in the country. To determine if the spread of this clonal strain was restricted to TEM-24-producing E. aerogenes strains, 84 E. aerogenes strains (non-TEM/SHV-producing strains, TEM-1- or -2-producing strains, and different ESBL-producing strains), isolated from 1988 to 1999 in Clermont-Ferrand (n = 59) and in 11 other French hospitals in 1998 (n = 25), were studied. A clonal strain was found for TEM-24- but also for TEM-3- and TEM-1- or 2-producing isolates. This study shows that there is a clonal strain dependent on acquisition of the TEM-type enzyme (TEM-24 and other TEM types).
摘要
1988年在法国克莱蒙费朗的肺炎克雷伯菌（bla(TEM - 24)）和产气肠杆菌（bla(TEM - 24b)）中检测到TEM - 24（CAZ - 6）超广谱β-内酰胺酶（ESBL），自1994年以来，在该国其他地方也观察到了一株产TEM - 24的产气肠杆菌克隆菌株。为了确定这种克隆菌株的传播是否仅限于产TEM - 24的产气肠杆菌菌株，对1988年至1999年在克莱蒙费朗（n = 59）以及1998年在法国其他11家医院（n = 25）分离出的84株产气肠杆菌菌株（非产TEM/SHV菌株、产TEM - 1或 - 2菌株以及不同的产ESBL菌株）进行了研究。发现产TEM - 24的菌株存在克隆菌株，产TEM - 3以及产TEM - 1或 - 2的分离株中也存在克隆菌株。这项研究表明，存在一种依赖于获得TEM型酶（TEM - 24和其他TEM类型）的克隆菌株。
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