New lanostanoids from the fungus Ganoderma concinna.

作者信息

González Antonio G, León Francisco, Rivera Augusto, Padrón Juan I, González-Plata Javier, Zuluaga Juan C, Quintana José, Estévez Francisco, Bermejo Jaime

机构信息

Instituto Universitario de Bio-Orgánica "Antonio González", Instituto de Productos Naturales y Agrobiología.-CSIC, Avenida Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Spain.

出版信息

J Nat Prod. 2002 Mar;65(3):417-21. doi: 10.1021/np010143e.

DOI:10.1021/np010143e

PMID:11908995

Abstract

Three new compounds, 5 alpha-lanosta-7,9(11),24-triene-3beta-hydroxy-26-al (1), 5 alpha-lanosta-7,9(11),24-triene-15 alpha-26-dihydroxy-3-one (2), and 8 alpha,9 alpha-epoxy-4,4,14 alpha-trimethyl-3,7,11,15,20-pentaoxo-5 alpha-pregnane (3), were isolated from Ganoderma concinna along with 12 known compounds. The structures of compounds 1 and 2 were determined on the basis of MS and NMR studies. The structure of 3 was determined by MS, NMR, and single-crystal X-ray diffraction. Compounds 1, 2, and 3 induce apoptosis in human promyelocytic leukemia HL-60 cells, as indicated by examining the morphological features of cells and detection of DNA fragmentation by gel electrophoresis.

摘要