烟曲霉临床分离株的弹性蛋白酶活性指数与侵袭性之间的相关性。
Correlation between the elastase activity index and invasiveness of clinical isolates of Aspergillus fumigatus.
作者信息
Blanco Jose L, Hontecillas Raquel, Bouza Emilio, Blanco Isabel, Pelaez Teresa, Muñoz Patricia, Perez Molina Jose, Garcia Marta E
机构信息
Departamento Patología Animal I, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain.
出版信息
J Clin Microbiol. 2002 May;40(5):1811-3. doi: 10.1128/JCM.40.5.1811-1813.2002.
Abstract
We calculated an elastase activity index (EAI) by dividing the diameter of the elastin lysis halo by the fungal growth diameter. After 10 days' incubation at 37 degrees C, all strains but one obtained from invasive aspergillosis showed an EAI > or = 1. Of the 18 strains obtained from colonized patients, only 4 (22.2%) had an EAI > or = 1, whereas neither of the strains isolated from patients with fungus ball reached this value. Overall, 44 out of the 142 strains obtained from the environment had an EAI > or = 1 (30.9%).
摘要
我们通过将弹性蛋白溶解晕的直径除以真菌生长直径来计算弹性蛋白酶活性指数（EAI）。在37℃孵育10天后，除了一株从侵袭性曲霉病中分离得到的菌株外，其他所有菌株的EAI均≥1。在从定植患者中获得的18株菌株中，只有4株（22.2%）的EAI≥1，而从曲菌球患者中分离出的菌株均未达到该值。总体而言，从环境中获得的142株菌株中有44株（30.9%）的EAI≥1。
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