红细胞与血浆之间的水交换。通过核磁共振弛豫进行测量。
Water exchange between red cells and plasma. Measurement by nuclear magnetic relaxation.
作者信息
Fabry M E, Eisenstadt M
出版信息
Biophys J. 1975 Nov;15(11):1101-10. doi: 10.1016/S0006-3495(75)85886-3.
Abstract
Water exchange between human red blood cells and the plasma phase was measured by water proton nuclear magnetic resonance relaxation in the presence of low concentrations of Mn(II) and by 17O relaxation of H217O in the absence of added Mn(II). The results were analyzed as a classic case of two-compartment exchange. The half-life for cell water at 25 degrees C was found to be 15 ms +/- 2 ms, longer than the time determined by other techniques. The T1 of the hemoglobin protons in the red cell and the volume of exchangeable water were also measured. The method appears to be a sensitive tool for the study of membrane permeability to water and other small molecules undergoing rapid exchange.
摘要
通过在低浓度锰（II）存在下利用水质子核磁共振弛豫以及在未添加锰（II）时利用H₂¹⁷O的¹⁷O弛豫来测量人体红细胞与血浆之间的水交换。结果作为两室交换的经典案例进行分析。发现在25摄氏度时细胞内水的半衰期为15毫秒±2毫秒，比其他技术测定的时间更长。还测量了红细胞中血红蛋白质子的T1以及可交换水的体积。该方法似乎是研究膜对水和其他进行快速交换的小分子的渗透性的灵敏工具。
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