MMWR Morb Mortal Wkly Rep. 2002 Aug 16;51(32):706-7.
Since Haemophilus influenzae type b (Hib) conjugate vaccines were introduced in the United States in 1990, the incidence of Hib invasive disease has declined markedly. The majority of cases of Haemophilus influenzae (Hi) disease are caused by organisms with capsule types other than b or by nontypeable organisms. One of the national health objectives for 2010 is to reduce to zero indigenous Hib invasive disease cases in children aged <5 years (objective 14-1c). In 2000, a total of 297 cases of invasive Hi disease were reported in children aged <5 years; serotype b represented 51 (22%) of 236 cases for which serotype information was known. This report describes inconsistencies in Hib serotyping between state health departments and CDC; these inconsistencies suggest that the burden of Hib disease might be less than estimated previously. Accurate laboratory information is essential for the accurate assessment of progress toward the elimination of Hib in the United States.
自1990年b型流感嗜血杆菌（Hib）结合疫苗在美国推出以来，Hib侵袭性疾病的发病率显著下降。大多数流感嗜血杆菌（Hi）疾病病例是由b型以外的荚膜型菌株或不可分型菌株引起的。2010年的一项国家卫生目标是将5岁以下儿童的本土Hib侵袭性疾病病例数降至零（目标14 - 1c）。2000年，5岁以下儿童共报告了297例侵袭性Hi疾病病例；在已知血清型信息的236例病例中，b血清型占51例（22%）。本报告描述了州卫生部门与疾病控制和预防中心（CDC）之间Hib血清分型的不一致情况；这些不一致表明Hib疾病的负担可能比先前估计的要小。准确的实验室信息对于准确评估美国消除Hib的进展至关重要。
