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茶儿茶素对HepG2细胞中细胞脂质过氧化和细胞毒性的影响。

Effect of tea catechins on cellular lipid peroxidation and cytotoxicity in HepG2 cells.

作者信息

Murakami Chikako, Hirakawa Yuki, Inui Hiroshi, Nakano Yoshihisa, Yoshida Hiromi

机构信息

Faculty of Nutrition, Kobe Gakuin University, Japan.

出版信息

Biosci Biotechnol Biochem. 2002 Jul;66(7):1559-62. doi: 10.1271/bbb.66.1559.

DOI:10.1271/bbb.66.1559
PMID:12224642
Abstract

Tea catechins inhibited TBARS accumulation in HepG2 cells, the order of effectiveness being (-)-epigallocatechin gallate (EGCG) > (-)-epigallocatechin (EGC) > or = (-)-epicatechin gallate (ECG) > (-)-epicatechin (EC). EGCG and EGC protected the depletion of alpha-tocopherol in the cells, and the glutathione content was enhanced by all four catechins. Moreover, all four catechins suppressed the formation of glutathione disulfide and the activation of glutathione peroxidase induced by tert-butylated hydroperoxide.

摘要

茶儿茶素抑制了HepG2细胞中硫代巴比妥酸反应物的积累，其有效性顺序为：（-）-表没食子儿茶素没食子酸酯（EGCG）＞（-）-表没食子儿茶素（EGC）＞或=（-）-表儿茶素没食子酸酯（ECG）＞（-）-表儿茶素（EC）。EGCG和EGC保护了细胞中α-生育酚的消耗，并且所有四种儿茶素均提高了谷胱甘肽含量。此外，所有四种儿茶素均抑制了叔丁基过氧化氢诱导的谷胱甘肽二硫化物的形成和谷胱甘肽过氧化物酶的激活。

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