Hultén Kerstin, Winkvist Anna, Lenner Per, Johansson Robert, Adlercreutz Herman, Hallmans Göran
Epidemiology Department of Public Health and Clinical Medicine, Umeå University, Sweden.
Eur J Nutr. 2002 Aug;41(4):168-76. doi: 10.1007/s00394-002-0373-3.
Using a nested case-referent design, we evaluated the relationship between plasma levels of the lignan enterolactone and the risk of developing breast cancer.
248 cases and 492 referents were selected from three population-based cohorts in northern Sweden. Blood samples were donated at enrollment. All blood samples were stored at -80 degrees C. Cases and referents were matched for age, date of blood sample and sampling centre. Breast cancer cases were identified through the regional and national cancer registries.
Plasma enterolactone was lower among smokers in all cohorts and in subjects with BMI < 23 and BMI > 28 in one of the cohorts. Low plasma concentrations of enterolactone, below the 12.5(th) percentile (mean plasma enterolactone 2.9 nmol/l), were associated with an increased risk of breast cancer. Also, high values of plasma enterolactone, above the 87.5(th) percentile (mean plasma enterolactone 58.2 nmol/l) were significantly associated with an increased breast cancer risk among women from two cohorts with only incident cases and a higher number of pre-menopausal women. High plasma enterolactone concentrations among older women from a mammary screening project with mostly prevalent cases were associated with a non-significant slightly reduced breast cancer risk.
Very low plasma concentrations of enterolactone were associated with an increased breast cancer risk in all three cohorts. In two of the cohorts, with only incident cases, very high plasma concentrations were also associated with an increased breast cancer risk. In the third cohort with mainly screen-detected cases from a mammary screening program, high plasma enterolactone concentrations were associated with a weak decreased breast cancer risk.
采用巢式病例对照设计，我们评估了木脂素肠内酯的血浆水平与患乳腺癌风险之间的关系。
从瑞典北部的三个人群队列中选取了248例病例和492例对照。在入组时捐献血样。所有血样均储存在-80℃。病例和对照按年龄、血样采集日期和采样中心进行匹配。乳腺癌病例通过地区和国家癌症登记处确定。
在所有队列中，吸烟者的血浆肠内酯水平较低，在其中一个队列中，体重指数（BMI）<23和BMI>28的受试者的血浆肠内酯水平也较低。血浆肠内酯浓度低，低于第12.5百分位数（平均血浆肠内酯2.9 nmol/l），与患乳腺癌风险增加相关。此外，在仅包含新发病例且绝经前女性数量较多的两个队列中，血浆肠内酯水平高于第87.5百分位数（平均血浆肠内酯58.2 nmol/l）与乳腺癌风险增加显著相关。在一个主要为现患病例的乳腺筛查项目中，老年女性血浆肠内酯浓度高与乳腺癌风险略有降低但无统计学意义相关。
在所有三个队列中，血浆肠内酯浓度极低与乳腺癌风险增加相关。在其中两个仅包含新发病例的队列中，血浆浓度极高也与乳腺癌风险增加相关。在第三个主要来自乳腺筛查项目筛查发现病例的队列中，血浆肠内酯浓度高与乳腺癌风险微弱降低相关。
