厚指软珊瑚素D - G，来自紫厚指软珊瑚的新型二萜类化合物。

Pachyclavulariaenones D-G, new diterpenoids from the soft coral Pachyclavularia violacea.

作者信息

Wang Guey-Horng, Sheu Jyh-Horng, Duh Chang-Yih, Chiang Michael Y

机构信息

Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan, Republic of China.

出版信息

J Nat Prod. 2002 Oct;65(10):1475-8. doi: 10.1021/np020095d.

DOI:10.1021/np020095d

PMID:12398546

Abstract

Four new diterpenoids, pachyclavulariaenones D-G (1-4), have been isolated from the soft coral Pachyclavularia violacea. The structures and relative stereochemistry of metabolites 1-4 were established on the basis of extensive NMR studies and chemical methods. The structure, including the relative configuration of pachyclavulariaenone F (3), was further confirmed by a single-crystal X-ray analysis. Pachyclavulariaenone G (4) has been shown to exhibit significant cytotoxicity toward P-388 and HT-29 cancer cells.

摘要

从软珊瑚紫厚指软珊瑚（Pachyclavularia violacea）中分离出了四种新的二萜类化合物，厚指软珊瑚烯酮D-G（1-4）。基于广泛的核磁共振研究和化学方法确定了代谢产物1-4的结构和相对立体化学。厚指软珊瑚烯酮F（3）的结构，包括其相对构型，通过单晶X射线分析得到了进一步证实。已证明厚指软珊瑚烯酮G（4）对P-388和HT-29癌细胞具有显著的细胞毒性。