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本文引用的文献

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Incidence of herpes simplex virus type 2 infection in the United States.美国2型单纯疱疹病毒感染的发病率。
Am J Epidemiol. 2001 May 1;153(9):912-20. doi: 10.1093/aje/153.9.912.
2
Characterization of an acyclovir-resistant herpes simplex virus type 2 strain isolated from a premature neonate.从一名早产新生儿分离出的阿昔洛韦耐药性单纯疱疹病毒2型毒株的特征分析。
J Infect Dis. 2000 Apr;181(4):1458-61. doi: 10.1086/315387. Epub 2000 Apr 13.
3
Antiviral drug susceptibility assays: going with the flow.抗病毒药物敏感性检测：顺应潮流
Antiviral Res. 1999 Aug;43(1):1-21. doi: 10.1016/s0166-3542(99)00039-x.
4
Treatment of mucocutaneous herpes simplex virus infections unresponsive to acyclovir with topical foscarnet cream in AIDS patients: a phase I/II study.艾滋病患者中对阿昔洛韦无反应的黏膜皮肤单纯疱疹病毒感染采用局部膦甲酸钠乳膏治疗：一项Ⅰ/Ⅱ期研究。
J Acquir Immune Defic Syndr. 1999 Aug 1;21(4):301-6. doi: 10.1097/00126334-199908010-00007.
5
New developments in the epidemiology, natural history and management of genital herpes.生殖器疱疹的流行病学、自然史及治疗的新进展。
Antiviral Res. 1999 May;42(1):1-14. doi: 10.1016/s0166-3542(99)00004-2.
6
Acyclovir-resistant herpes simplex virus infections in a bone marrow transplant population.骨髓移植人群中对阿昔洛韦耐药的单纯疱疹病毒感染
Bone Marrow Transplant. 1998 Sep;22(6):587-9. doi: 10.1038/sj.bmt.1701392.
7
Rapid ganciclovir susceptibility assay using flow cytometry for human cytomegalovirus clinical isolates.使用流式细胞术对人巨细胞病毒临床分离株进行更昔洛韦快速药敏试验。
Antimicrob Agents Chemother. 1998 Sep;42(9):2326-31. doi: 10.1128/AAC.42.9.2326.
8
Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients.免疫功能低下患者中阿昔洛韦耐药单纯疱疹病毒的表型和基因型特征
J Infect Dis. 1998 Aug;178(2):297-303. doi: 10.1086/515626.
9
Rapid screening tests for determining in vitro susceptibility of herpes simplex virus clinical isolates.用于确定单纯疱疹病毒临床分离株体外敏感性的快速筛查试验。
J Clin Microbiol. 1998 Aug;36(8):2389-91. doi: 10.1128/JCM.36.8.2389-2391.1998.
10
Survey of resistance of herpes simplex virus to acyclovir in northwest England.英格兰西北部单纯疱疹病毒对阿昔洛韦的耐药性调查。
Antimicrob Agents Chemother. 1998 Apr;42(4):868-72. doi: 10.1128/AAC.42.4.868.

使用单一单克隆抗体来确定1型和2型单纯疱疹病毒临床分离株对阿昔洛韦的敏感性。

Use of a single monoclonal antibody to determine the susceptibilities of herpes simplex virus type 1 and type 2 clinical isolates to acyclovir.

作者信息

Chutkowski Christine, Olson Betty, McDonough Ann, Mahoney James, McSharry James J

机构信息

Center for Immunology and Microbial Disease, Albany Medical Center, Albany, New York 12208, USA.

出版信息

Clin Diagn Lab Immunol. 2002 Nov;9(6):1379-81. doi: 10.1128/cdli.9.6.1379-1381.2002.

DOI:10.1128/cdli.9.6.1379-1381.2002
PMID:12414779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC130122/
Abstract

This report describes a flow cytometry drug susceptibility assay that uses a single fluorochrome-labeled monoclonal antibody to determine the acyclovir susceptibilities of herpes simplex virus (HSV) type 1 or type 2 clinical isolates. This assay yields 50% effective doses (drug concentrations that reduce the number of antigen-positive cells by 50%) for HSV clinical isolates that are equivalent to those obtained with the plaque reduction assay.

摘要

本报告描述了一种流式细胞术药物敏感性检测方法，该方法使用单一荧光染料标记的单克隆抗体来确定1型或2型单纯疱疹病毒（HSV）临床分离株对阿昔洛韦的敏感性。对于HSV临床分离株，该检测方法得出的50%有效剂量（使抗原阳性细胞数量减少50%的药物浓度）与蚀斑减少检测法得出的结果相当。