Khan Z A, Assiri A M, Al-Afghani H M, Maghrabi T M
Department of Biochemistry, Faculty of Medicine and Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Int Urol Nephrol. 2001;33(4):605-8. doi: 10.1023/a:1020526517097.
We investigated the effect of Ammi visnaga seeds on experimentally - induced kidney stones - in male Wistar albino rats. Oxalate nephrolithiasis was experimentally induced by 3% glycolic acid (added in their diet) given for the period of four weeks. A highly significant amount of deposits were found in the kidneys, which were analyzed quantitatively. These deposits were mainly of calcium oxalate in composition. Daily oral (gavage) treatment with Ammi visnaga (500 mg/kg) highly reduced the incidence of nephrolithiasis (calcium oxalate deposition in the kidneys). Ammi visnaga seeds extract showed highly potent diuretic activity. The reduction in body weight, increase in kidneys weight, increase in water intake, decrease in urine output found in glycolic acid control group were prevented to various extent on Ammi visnaga treatment; and the values became to insignificant difference with control group. The changes in weights of liver, heart and lungs of the three groups were insignificant. Uraemia and hyperbilirubinaemia observed in glycolic acid control group were found to be ameliorated by Ammi visnaga seed extract treatment.
我们研究了阿米茴芹籽对雄性Wistar白化大鼠实验性诱导肾结石的影响。通过在四周内给予3%乙醇酸（添加到它们的饮食中）来实验性诱导草酸盐肾结石。在肾脏中发现了大量沉积物，并对其进行了定量分析。这些沉积物主要由草酸钙组成。每日口服（灌胃）阿米茴芹（500毫克/千克）可显著降低肾结石的发生率（肾脏中草酸钙沉积）。阿米茴芹籽提取物显示出高效的利尿活性。乙醇酸对照组中出现的体重减轻、肾脏重量增加、饮水量增加、尿量减少在接受阿米茴芹治疗后在不同程度上得到了预防；并且这些值与对照组相比变得无显著差异。三组的肝脏、心脏和肺的重量变化不显著。发现乙醇酸对照组中观察到的尿毒症和高胆红素血症通过阿米茴芹籽提取物治疗得到了改善。
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