Herman Paul K
Department of Molecular Genetics, The Ohio State University, 484 West Twelfth Avenue, Room 984, Columbus, Ohio 43210, USA.
Curr Opin Microbiol. 2002 Dec;5(6):602-7. doi: 10.1016/s1369-5274(02)00377-6.
Eukaryotic cell proliferation is controlled by specific growth factors and the availability of essential nutrients. If either of these signals is lacking, cells may enter into a specialized nondividing resting state, known as stationary phase or G(0). The entry into such resting states is typically accompanied by a dramatic decrease in the overall growth rate and an increased resistance to a variety of environmental stresses. Since most cells spend most of their life in these quiescent states, it is important that we develop a full understanding of the biology of the stationary phase/G(0) cell. This knowledge would provide important insights into the control of two of the most fundamental aspects of eukaryotic cell biology: cell proliferation and long-term cell survival. This review will discuss some recent advances in our understanding of the stationary phase of growth in the budding yeast, Saccharomyces cerevisiae.
真核细胞增殖受特定生长因子和必需营养物质可用性的控制。如果这些信号中的任何一个缺失，细胞可能进入一种特殊的非分裂静止状态，即静止期或G(0)期。进入这种静止状态通常伴随着总体生长速率的显著下降以及对各种环境压力的抵抗力增强。由于大多数细胞在这些静止状态中度过其大部分生命，因此我们全面了解静止期/G(0)期细胞的生物学特性非常重要。这一知识将为真核细胞生物学两个最基本方面的控制提供重要见解：细胞增殖和细胞长期存活。本综述将讨论我们对芽殖酵母酿酒酵母生长静止期理解的一些最新进展。
