Chan Shelley L, Chan-Yeung Moira M, Ooi Gaik C, Lam Cindy L, Cheung Tung F, Lam Wah K, Tsang Kenneth W
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region.
Chest. 2002 Dec;122(6):2030-7. doi: 10.1378/chest.122.6.2030.
To validate the Hong Kong Chinese version of the St. George Respiratory Questionnaire (SGRQ-HK) in patients with bronchiectasis.
Outpatients (93 patients; 61 women; mean age [+/- SD], 59.0 +/- 14.2 years) were assessed at baseline by the SGRQ-HK, the Hong Kong Chinese version of the 36-item short form health survey (SF-36-HK), and the hospital anxiety and depression scale (HADS). Forty randomly selected patients also were reassessed at 2 weeks for repeatability. Seventy-two patients were further reassessed at 6 months for responsiveness.
Cronbach alpha coefficients, which reflected internal consistency, were > 0.7 for all SGRQ-HK components except for symptoms (alpha = 0.59), and the intraclass correlation coefficients between baseline and the 2-week follow-up visits were between 0.80 and 0.94 (p > 0.05). SGRQ-HK component scores and total scores correlated with all the component scores of the SF-36-HK and the HADS (p < 0.02). SGRQ-HK component scores and total scores correlated with the scores of the SF-36-HK and the HADS, confirming the concurrent validity. All SGRQ-HK scores correlated negatively with FEV(1), FVC, and arterial oxygen saturation (p < 0.005), while the activity score correlated with the Karnofsky performance scale and the number of bronchiectatic lobes (p < 0.001). SGRQ-HK scores positively correlated with Borg scale scores, exacerbation frequency, and 24-h sputum volumes (p < 0.03). Patients with 24-h sputum volumes of > or = 10 mL or < 10 mL had significantly different SQRG-HK component scores and total scores (p < 0.002), although this sensitivity was not displayed by scores on the HADS or the SF-36-HK. Patients with 25% reductions in 24-h sputum volumes had significant improvements in SGRQ-HK activity scores, impact scores, and total scores (p < 0.02), but not in other quality-of-life measures or clinical parameters, indicating the responsiveness of the SGRQ-HK.
The SGRQ-HK is a valid and sensitive instrument for determining quality of life in bronchiectasis patients.
验证圣乔治呼吸问卷香港中文版（SGRQ-HK）在支气管扩张症患者中的有效性。
对门诊患者（93例；61例女性；平均年龄[±标准差]，59.0±14.2岁）在基线时采用SGRQ-HK、香港中文版36项简短健康调查问卷（SF-36-HK）和医院焦虑抑郁量表（HADS）进行评估。随机选取40例患者在2周时进行重复评估以检验重复性。72例患者在6个月时进一步进行重新评估以检验反应性。
反映内部一致性的Cronbach α系数，除症状部分（α = 0.59）外，SGRQ-HK各部分均>0.7，基线与2周随访之间的组内相关系数在0.80至0.94之间（p>0.05）。SGRQ-HK各部分得分及总分与SF-36-HK和HADS的所有部分得分均相关（p<0.02）。SGRQ-HK各部分得分及总分与SF-36-HK和HADS的得分相关，证实了同时效度。SGRQ-HK所有得分均与第1秒用力呼气容积（FEV₁）、用力肺活量（FVC）和动脉血氧饱和度呈负相关（p<0.005），而活动得分与卡氏功能状态量表及支气管扩张肺叶数量相关（p<0.001）。SGRQ-HK得分与博格量表得分、急性加重频率和24小时痰液量呈正相关（p<0.03）。24小时痰液量≥10 mL或<10 mL的患者，SQRG-HK各部分得分及总分有显著差异（p<0.002），尽管HADS或SF-36-HK得分未显示出这种敏感性。24小时痰液量减少25%的患者，SGRQ-HK活动得分、影响得分及总分有显著改善（p<0.02），但在其他生活质量指标或临床参数方面无改善，表明SGRQ-HK具有反应性。
SGRQ-HK是一种用于确定支气管扩张症患者生活质量的有效且敏感的工具。
