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缺陷型流感病毒的转录酶活性与基因组组成

Transcriptase activity and genome composition of defective influenza virus.

作者信息

Bean W J, Simpson R W

出版信息

J Virol. 1976 Apr;18(1):365-9. doi: 10.1128/JVI.18.1.365-369.1976.

DOI:10.1128/JVI.18.1.365-369.1976
PMID:1255876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC515556/
Abstract

Eight genome RNA segments are present in both normal and von Magnustype influenza virus preparations and all species are transcribed by the virion-associated polymerase. Although the RNA polymerase activity and the amount of the three largest RNA segments are reduced in defective influenza virus preparations, these reductions do not appear to be great enough to account for the much greater loss of infectivity.

摘要

正常的和冯·马格努斯型流感病毒制剂中都存在八个基因组RNA片段,并且所有片段都由病毒体相关的聚合酶转录。尽管在缺陷型流感病毒制剂中RNA聚合酶活性以及三个最大RNA片段的量有所降低,但这些降低似乎不足以解释传染性的大幅损失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/515556/34661327bb0d/jvirol00220-0383-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/515556/34661327bb0d/jvirol00220-0383-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/515556/34661327bb0d/jvirol00220-0383-a.jpg

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本文引用的文献

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The multiplication of influenza virus. I. The formation of incomplete virus.流感病毒的增殖。I. 不完全病毒的形成。
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Transcription of the influenza ribonucleic acid genome by a virion polymerase. II. Nature of the in vitro polymerase product.流感病毒核糖核酸基因组由病毒粒子聚合酶进行转录。II. 体外聚合酶产物的性质。
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