Alspaugh M A, Buchanan W W, Whaley K
Ann Rheum Dis. 1978 Jun;37(3):244-6. doi: 10.1136/ard.37.3.244.
The prevalence of three precipitating antibodies, anti-SS-A anti-SS-B, and rheumatoid arthritis precipitin (RAP), reacting with an extract of the human lymphoid cell line Wil2, was studied in the sicca syndrome, Sjögren's syndrome with rheumatoid arthritis, rheumatoid arthritis, various seronegative spondyloarthritides, and organ and nonorgan-specific autoimmune disease. Anti-SS-A and snti-SS-B occurred most frequently in the sera of patients with the sicca syndrome whereas RAP occurred most frequently in seropositive rheumatoid arthritis sera. However, the data did not support previous studies where patients with sicca syndrome had a high incidence of anti-SS-A and/or -SS-B antibodies but had a low frequency of RAP, and patients with Sjögren's syndrome in association with rheumatoid arthritis had a high incidence of RAP but a low incidence of anti-SS-A and/or -SS-B. Instead the three antibodies were present in both forms of Sjögren's syndrome. This suggested a difference in the diseases in the UK compared to the USA, or that these antibodies do not have the more subtle diagnostic specificity that was originally suggested.
我们研究了三种沉淀抗体，即抗SS - A、抗SS - B和类风湿关节炎沉淀素（RAP）与人类淋巴细胞系Wil2提取物反应的情况，研究对象包括干燥综合征、合并类风湿关节炎的干燥综合征、类风湿关节炎、各种血清阴性脊柱关节炎以及器官特异性和非器官特异性自身免疫性疾病。抗SS - A和抗SS - B在干燥综合征患者血清中出现频率最高，而RAP在血清阳性类风湿关节炎患者血清中出现频率最高。然而，这些数据并不支持先前的研究结果，即干燥综合征患者抗SS - A和/或抗SS - B抗体发生率高但RAP频率低，合并类风湿关节炎的干燥综合征患者RAP发生率高但抗SS - A和/或抗SS - B发生率低。相反，这三种抗体在两种形式的干燥综合征中均有出现。这表明与美国相比，英国的这些疾病存在差异，或者这些抗体并不具有最初所认为的更细微的诊断特异性。
