父亲年龄与低出生体重、早产和多胎生育风险增加有关吗？
Is paternal age associated with an increased risk of low birthweight, preterm delivery, and multiple birth?
作者信息
Tough Suzanne C, Faber Alexandra J, Svenson Lawrence W, Johnston David W
机构信息
Pediatrics and Community Health Sciences, University of Calgary, Calgary, AB.
出版信息
Can J Public Health. 2003 Mar-Apr;94(2):88-92. doi: 10.1007/BF03404578.
OBJECTIVE
To determine if paternal age elevates the risk of low birthweight (< 2500g, LBW), preterm birth (< 37 weeks gestation), and multiple gestation among mothers whose age does not predict an elevated risk.
DESIGN/METHODS: Population data on birth outcome, maternal age and paternal age was obtained from Alberta Health and Wellness for all births 1990-1996.
RESULTS
Among women aged 25 to 29, regardless of parity, there was no linear relationship between paternal age and preterm birth or LBW. However, multiple birth rates increased with increased paternal age (p < 0.01). Among singleton births, advanced paternal age (>50 years) increased the risk of LBW and preterm birth (p < 0.05).
CONCLUSIONS
Paternal age is not a risk factor for LBW or preterm delivery among low risk women. The increased risk of multiple birth with increased paternal age, regardless of parity, requires confirmation among other populations.
目的
确定对于年龄未显示出风险升高的母亲，父亲年龄是否会增加低出生体重（<2500克，LBW）、早产（妊娠<37周）和多胎妊娠的风险。
设计/方法：从艾伯塔省健康与福利部获取了1990 - 1996年所有出生的出生结局、母亲年龄和父亲年龄的人口数据。
结果
在25至29岁的女性中，无论胎次如何，父亲年龄与早产或低出生体重之间均无线性关系。然而，多胎出生率随父亲年龄的增加而上升（p < 0.01）。在单胎分娩中，父亲年龄较大（>50岁）会增加低出生体重和早产的风险（p < 0.05）。
结论
对于低风险女性，父亲年龄不是低出生体重或早产的风险因素。无论胎次如何，父亲年龄增加导致多胎妊娠风险增加这一情况，需要在其他人群中得到证实。
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