大黄素甲醚8-O-β-D-葡萄糖苷，一种新的硫酸化蒽醌苷，以及来自喜马拉雅大黄的抗氧化酚类化合物。

Sulfemodin 8-O-beta-D-glucoside, a new sulfated anthraquinone glycoside, and antioxidant phenolic compounds from Rheum emodi.

作者信息

Krenn Liselotte, Presser Armin, Pradhan Riddhi, Bahr Beate, Paper Dietrich H, Mayer Klaus K, Kopp Brigitte

机构信息

Institute of Pharmacognosy, University of Vienna, Pharmacy-Center, Althanstrasse 14, A-1090 Vienna, Austria.

出版信息

J Nat Prod. 2003 Aug;66(8):1107-9. doi: 10.1021/np0301442.

DOI:10.1021/np0301442

PMID:12932135

Abstract

A sulfated emodin glucoside, emodin 8-O-beta-D-glucopyranosyl-6-O-sulfate (1), was isolated from the roots of Rheum emodi in an investigation of the active constituents of this Nepalese medicinal plant, and its structure was determined by spectroscopic and chemical methods. Additionally, two rare auronols, carpusin (2) and maesopsin (3), besides other anthraquinones and phenolics, were isolated and identified. Compounds 2 and 3 showed significant antioxidant activity in the DPPH assay, while chrysophanol, physcion, and emodin and their 8-O-glucosides were found to be inactive.

摘要

在对这种尼泊尔药用植物的活性成分进行研究时，从大黄的根中分离出一种硫酸化大黄素糖苷，大黄素8-O-β-D-吡喃葡萄糖苷-6-O-硫酸盐（1），并通过光谱和化学方法确定了其结构。此外，除了其他蒽醌和酚类化合物外，还分离并鉴定出两种罕见的奥罗醇，腕菌素（2）和山扁豆素（3）。化合物2和3在DPPH测定中显示出显著的抗氧化活性，而大黄酚、大黄素甲醚、大黄素及其8-O-葡萄糖苷则无活性。