Karlberg Johan, Kwan Chi-Wai, Gelander Lars, Albertsson-Wikland Kerstin
Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Horm Res. 2003;60(Suppl 1):27-35. doi: 10.1159/000071223.
Almost all available sets of height growth reference values are constructed in a cross-sectional manner, except for a few studies in which longitudinal sampling was used. Such reference values are, however, flawed because of considerable individual variation in the timing of puberty, especially among children with early or late pubertal maturation. An additional complicating factor is that the magnitude of the total pubertal growth spurt is significantly larger among those individuals with early pubertal maturation, compared with late maturation. Based on the growth records of 145 healthy Swedish children followed longitudinally, this study introduces a pre-pubertal standard for the assessment of pre-pubertal height for children with late onset of puberty. By plotting the height values of a child in a chart containing pre-pubertal reference values, the onset of the pubertal growth spurt can be identified by a change in the pre-pubertal height standard deviation score values of 0.3 standard deviations or more over a period of 1 year. Once the pubertal onset is established, a highly accurate final height prediction method can be applied to the data, as described in this article, in which height and age at pubertal onset are the only two measures required. The r(2) value of the prediction model was over 0.80 for both sexes. Finally, a method for assessing total pubertal height gain is presented. The method adjusts for the timing of puberty and is based on the height and age at pubertal onset, plus the observed final height.
几乎所有现有的身高增长参考值数据集都是以横断面方式构建的,只有少数研究采用纵向抽样。然而,由于青春期时间存在相当大的个体差异,尤其是在青春期早熟或晚熟的儿童中,此类参考值存在缺陷。另一个复杂因素是,与青春期晚熟个体相比,青春期早熟个体的青春期总生长突增幅度明显更大。基于对145名瑞典健康儿童的纵向生长记录,本研究引入了一种青春期前标准,用于评估青春期晚发儿童的青春期前身高。通过将儿童的身高值绘制在包含青春期前参考值的图表中,青春期生长突增的开始可以通过青春期前身高标准差分值在1年内变化0.3个标准差或更多来确定。一旦确定了青春期开始时间,就可以将一种高度准确的最终身高预测方法应用于这些数据,如本文所述,其中青春期开始时的身高和年龄是所需的仅有的两项测量指标。该预测模型的r(2)值在两性中均超过0.80。最后,提出了一种评估青春期总身高增长的方法。该方法根据青春期时间进行调整,并且基于青春期开始时的身高和年龄,加上观察到的最终身高。