Menzel Matthias, Soukup Jens, Henze Dirk, Engelbrecht Kai, Senderreck Maik, Scharf Alexander, Rieger Andreas, Grond Stefan
Dept. of Anesthesiology and Intensive Care Medicine, Martin-Luther-University, Magdeburger Strasse 16, 06097, Halle, Germany.
Intensive Care Med. 2003 Dec;29(12):2180-2186. doi: 10.1007/s00134-003-1962-1. Epub 2003 Sep 3.
The utility of continuous intra-arterial blood gas analysis (CBGA) with combined electrochemical and optode sensors has been demonstrated. More recently, a pure optode sensor with a changed sensing element architecture has become available. The aim was to determine the measurement accuracy and long-term stability of the new sensor.
A prospective explorative study was performed. Simultaneous measurements of intermittent blood gas analyses (IBGA) (ABL 610, Radiometer, Copenhagen) and CBGA (Diametrics Medical, High Wycombe, Bucks., UK) were compared using Bland-Altman analysis.
Twenty-five patients admitted to the ICU and requiring mechanical ventilation for an expected minimum of about 96 h were included.
Mean monitoring time was 106.1 (range 15-231) hours. Bias and precision for PO(2 )were -0.2 kPa (1%)+/-1.8 kPa (9.5%); PCO(2): 0.03 kPa (0.6%)+/-0.44 kPa (9.3%); pH: -0.001 (0.01%)+/-0.04 (0.45%). The sensor showed no change of measurement characteristics during 4 days of measurement. However, in 69 cases continuous monitoring was interrupted (reversible sudden drops of PO(2) measurement) possibly caused by thrombotic deposition and/or sensor bending and accidental sensor retraction.
The precision and bias of the PCO(2)- and pH-sensing elements were in line with the findings of the older sensor technology. The possibility that the PO(2) optode could offer greater accuracy than the older technology is suggested by comparisons with results reported in previous studies. No sensor drift occurred during long-term measurement over more than 4 days.
已证实采用电化学和光极传感器相结合的连续动脉血气分析（CBGA）的实用性。最近，一种具有改变的传感元件结构的纯光极传感器已经面市。目的是确定新型传感器的测量准确性和长期稳定性。
进行了一项前瞻性探索性研究。使用Bland-Altman分析比较了间歇血气分析（IBGA）（ABL 610，雷度米特公司，哥本哈根）和CBGA（直径医疗公司，海威科姆，巴克斯，英国）的同步测量结果。
纳入了25名入住重症监护病房且预计至少需要机械通气约96小时的患者。
平均监测时间为106.1（范围15 - 231）小时。PO₂的偏差和精密度为-0.2 kPa（1%）±1.8 kPa（9.5%）；PCO₂：0.03 kPa（0.6%）±0.44 kPa（9.3%）；pH：-0.001（0.01%）±0.04（0.45%）。在4天的测量过程中，传感器的测量特性没有变化。然而，但在69例中，连续监测中断（PO₂测量值突然可逆性下降），可能是由血栓沉积和/或传感器弯曲以及传感器意外回缩引起的。
PCO₂和pH传感元件的精密度和偏差与旧传感器技术的结果一致。与先前研究报告的结果比较表明，PO₂光极可能比旧技术提供更高的准确性。在超过4天的长期测量中未发生传感器漂移。
