Dapueto Juan J, Francolino Carla, Servente Liliana, Chang Chih-Hung, Gotta Irene, Levin Roberto, Abreu María Del Carmen
Departamento de Psicología Médica, Facultad de Medicina - Universidad de República, Uruguay.
Health Qual Life Outcomes. 2003 Aug 20;1:32. doi: 10.1186/1477-7525-1-32.
The FACT-G has gone through many validation studies. However, little research has been conducted in South American Spanish speaking patients. The present study aimed to evaluate the FACT-G Spanish Version 4 in Uruguayan cancer patients.
The data analyzed were collected from 309 patients, with various tumor sites, at different stages of disease and receiving different treatments.
Reliability was evaluated using Cronbach's coefficient alpha and showed high internal consistency for each of the subscales and its total scale (range =.78 -.91) of the FACT-G. The FACT-G total score also showed significant mean differences among known groups (performance status, in vs. outpatients) when tested by ANOVA and t-test. When the tumor stage (Local and Regional vs. Metastatic disease) was used as a clinical anchor, the FACT-G total score, the Physical Well-being (PWB), and Functional Well-being (FWB) subscale scores showed mean differences, ranging from 5 to 10 points in a scale from 0-108 (effect sizes = 0.30-0.60). Item response theory (IRT)-based evaluation using mean square fit statistics (.60-1.4) criteria showed that only two items misfit: "Estoy satisfecho(a) con mi vida sexual" (I am satisfied with my sex life) and "Estoy satisfecho(a) de cómo estoy enfrentando mi enfermedad" (I am satisfied with how I am coping with my illness).
The results indicated that, using both traditional and IRT approaches, the Spanish FACT-G has good reliability and validity to be used as a QOL instrument among Uruguayan cancer patients.
FACT-G已历经多项效度验证研究。然而，针对南美说西班牙语的患者开展的研究甚少。本研究旨在评估乌拉圭癌症患者中FACT-G西班牙语第4版的情况。
分析的数据收集自309例患者，这些患者肿瘤部位各异，处于疾病的不同阶段且接受不同治疗。
使用克朗巴哈系数α评估信度，结果显示FACT-G各子量表及其总量表均具有较高的内部一致性（范围=0.78 - 0.91）。通过方差分析和t检验，FACT-G总分在已知组（身体状况，住院患者与门诊患者）之间也显示出显著的均值差异。当将肿瘤分期（局部和区域期与转移性疾病）作为临床锚定时，FACT-G总分、生理健康（PWB）和功能健康（FWB）子量表得分显示出均值差异，在0 - 108分的量表上差异范围为5至10分（效应量=0.30 - 0.60）。基于项目反应理论（IRT）使用均方拟合统计量（0.60 - 1.4）标准进行的评估表明，只有两个项目拟合不佳：“Estoy satisfecho(a) con mi vida sexual”（我对我的性生活感到满意）和“Estoy satisfecho(a) de cómo estoy enfrentando mi enfermedad”（我对自己应对疾病的方式感到满意）。
结果表明，采用传统方法和IRT方法，西班牙语版FACT-G在乌拉圭癌症患者中作为生活质量工具具有良好的信度和效度。
