Edwards S, Small J D, Geratz J D, Alexander L K, Baric R S
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599-7400.
J Infect Dis. 1992 Jan;165(1):134-40. doi: 10.1093/infdis/165.1.134.
In a model for virus-induced myocarditis and congestive heart failure, rabbit coronavirus infection was divided into acute (days 2-5) and subacute (days 6-12) phases on the basis of day of death and pathologic findings. During the acute phase, the principal histologic lesions were degeneration and necrosis of myocytes, myocytolysis, interstitial edema, and hemorrhage. The severity of these changes increased in the subacute phase. Pleural effusion and congestion of the lungs and liver were also present at this time. Myocarditis was detected by day 9 and peaked by day 12. Heart weights and heart weight-to-body weight ratios were increased, and dilation of the right ventricular cavity became prominent early in infection and persisted. In contrast, dilation of the left ventricle occurred late in the subacute stage. Virus was isolated from infected hearts between days 2 and 12. These data suggest that rabbit coronavirus infection progresses to myocarditis and congestive heart failure.
在一种病毒诱导的心肌炎和充血性心力衰竭模型中，根据死亡时间和病理结果，家兔冠状病毒感染被分为急性期（第2 - 5天）和亚急性期（第6 - 12天）。在急性期，主要的组织学病变是心肌细胞变性、坏死、肌细胞溶解、间质水肿和出血。这些变化的严重程度在亚急性期增加。此时还出现胸腔积液以及肺和肝脏充血。心肌炎在第9天被检测到，并在第12天达到高峰。心脏重量和心脏重量与体重之比增加，右心室腔扩张在感染早期就很明显并持续存在。相比之下，左心室扩张发生在亚急性期后期。在第2天至第12天之间从受感染的心脏中分离出病毒。这些数据表明，家兔冠状病毒感染会发展为心肌炎和充血性心力衰竭。
