厄瓜多尔和德国儿童中针对6型人类轮状病毒PA151和PA169的中和血清抗体
Neutralizing serum antibodies to serotype 6 human rotaviruses PA151 and PA169 in Ecuadorian and German children.
作者信息
Brüssow H, Gerna G, Sidoti J, Sarasini A
机构信息
Nestlé Research Centre, Nestec Ltd., Lausanne, Switzerland.
出版信息
J Clin Microbiol. 1992 Apr;30(4):911-4. doi: 10.1128/jcm.30.4.911-914.1992.
Serum samples from 726 Ecuadorian children who underwent natural rotavirus (RV) exposure were tested for neutralizing serum antibodies against two serotype 6 (ST6) human RV (HRV) isolates from Italy, PA151 and PA169, and two ST6 bovine RV (BRV) isolates, NCDV and UK. Gene 4 was distinct in all four ST6 strains. Ninety-one, 56, 67, and 65 serum samples neutralized HRV PA151 (13%), HRV PA169 (8%), BRV NCDV (9%), and BRV UK (9%), respectively. A total of 44 of the 91 serum samples which neutralized HRV PA151 did not neutralize the other three ST6 RV strains. In addition, we identified three serum samples that neutralized HRV PA151 but none of the six human or four animal RV STs. However, we failed to identify serum samples that neutralized HRV PA169 without neutralizing at least one of the major HRV STs. With a hospital-based serum collection from German children (excluding gastroenteritis patients), we identified 3 out of 197 serum samples tested that neutralized HRV PA151 specifically, whereas none neutralized HRV PA169 exclusively. None of the 71 German infants hospitalized with primary RV gastroenteritis showed a PA151- or a PA169-specific antibody response.
对726名自然感染轮状病毒（RV）的厄瓜多尔儿童的血清样本进行检测，以分析其针对来自意大利的两株6型（ST6）人轮状病毒（HRV）分离株PA151和PA169以及两株ST6牛轮状病毒（BRV）分离株NCDV和UK的血清中和抗体。所有四株ST6毒株的基因4均不同。分别有91份、56份、67份和65份血清样本中和了HRV PA151（13%）、HRV PA169（8%）、BRV NCDV（9%）和BRV UK（9%）。在91份中和了HRV PA151的血清样本中，共有44份不能中和其他三株ST6 RV毒株。此外，我们鉴定出三份血清样本，它们能中和HRV PA151，但不能中和六株人源或四株动物源RV STs中的任何一株。然而，我们未能鉴定出能中和HRV PA169但不中和至少一种主要HRV STs的血清样本。在对德国儿童（不包括肠胃炎患者）进行的基于医院的血清采集检测中，我们在197份检测的血清样本中鉴定出3份能特异性中和HRV PA151的样本，而没有样本能单独中和HRV PA169。71名因原发性RV肠胃炎住院的德国婴儿均未表现出针对PA151或PA169的特异性抗体反应。
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