Have P, Moving V, Svansson V, Uttenthal A, Bloch B
State Veterinary Institute for Virus Research, Lindholm, Kalvehave, Denmark.
Vet Microbiol. 1992 Apr;31(1):1-10. doi: 10.1016/0378-1135(92)90135-g.
Antibodies to a transmissible gastroenteritis virus (TGEV)-related coronavirus have been demonstrated in mink sera by indirect immunofluorescence, peroxidase-linked antibody assays and immunoblotting. This is the first serological evidence of a specific coronavirus infection in mink. The putative mink coronavirus (MCV) seems to be widespread in the Danish mink population with a prevalence approaching 100%. Analysis by immunoblotting has shown that MCV is closely related to TGEV by the spike (S), matrix (M) and nucleoprotein (N) polypeptides. Furthermore, antibodies to MCV also cross-reacted with N and M polypeptides of porcine epidemic diarrhea virus (PEDV). Thus MCV may occupy an intermediate position between the TGEV group of coronavirus and PEDV. The possibility that MCV may be associated with syndromes of acute enteritis in preweaning mink is discussed.
通过间接免疫荧光、过氧化物酶联抗体测定和免疫印迹法，已在水貂血清中证实存在针对一种与传染性胃肠炎病毒（TGEV）相关的冠状病毒的抗体。这是水貂中特定冠状病毒感染的首个血清学证据。假定的水貂冠状病毒（MCV）似乎在丹麦水貂种群中广泛传播，流行率接近100%。免疫印迹分析表明，MCV在刺突（S）、基质（M）和核蛋白（N）多肽方面与TGEV密切相关。此外，针对MCV的抗体也与猪流行性腹泻病毒（PEDV）的N和M多肽发生交叉反应。因此，MCV可能在冠状病毒的TGEV组和PEDV之间占据中间位置。文中讨论了MCV可能与断奶前水貂急性肠炎综合征相关的可能性。
