Gray J J, Caldwell J, Sillis M
Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge, U.K.
J Infect. 1992 Jul;25(1):39-46. doi: 10.1016/0163-4453(92)93465-3.
A total of 121 samples of serum collected from 101 patients was tested to determine the sensitivity and specificity of a commercial latex agglutination test for detecting infectious mononucleosis heterophile antibody, a commercial immunofluorescence test for detecting antibody to Epstein-Barr virus capsid antigen and a rapid enzyme immunoassay for detecting antibody to Epstein-Barr virus nuclear antigen. Although the Epstein-Barr virus capsid antigen IgM indirect immunofluorescence test proved to be the most sensitive, false-positive reactions were seen when samples collected from patients with cytomegalovirus, hepatitis A virus, parvovirus and leptospira infection were tested. False-positive reactions were also seen with samples containing rheumatoid factor.
对从101名患者采集的总共121份血清样本进行检测，以确定用于检测传染性单核细胞增多症嗜异性抗体的商用乳胶凝集试验、用于检测爱泼斯坦-巴尔病毒衣壳抗原抗体的商用免疫荧光试验以及用于检测爱泼斯坦-巴尔病毒核抗原抗体的快速酶免疫测定的敏感性和特异性。尽管爱泼斯坦-巴尔病毒衣壳抗原IgM间接免疫荧光试验被证明是最敏感的，但对从巨细胞病毒、甲型肝炎病毒、细小病毒和钩端螺旋体感染患者采集的样本进行检测时出现了假阳性反应。含有类风湿因子的样本也出现了假阳性反应。
