急性弯曲杆菌胃肠道感染中对弯曲杆菌鞭毛蛋白的局部免疫反应。
Local immune responses to the Campylobacter flagellin in acute Campylobacter gastrointestinal infection.
作者信息
Nachamkin I, Yang X H
机构信息
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.
出版信息
J Clin Microbiol. 1992 Feb;30(2):509-11. doi: 10.1128/jcm.30.2.509-511.1992.
Abstract
Intestinal immunoglobulin A (IgA) anti-campylobacter flagellin antibodies were measured by an enzyme-linked immunosorbent assay in patients with and without campylobacter infections. The level of fecal IgA antiflagellin antibodies was significantly higher in patients than in controls, but only 12 of 29 patients (41.4%) with a campylobacter infection had detectable IgA antibodies against flagellin (optical density, greater than or equal to 0.100). Further testing of fecal IgA antibodies from 10 patients with homologous and heterologous purified flagellins showed strain specificity in 1 patient. Cross-reactivity of fecal IgA antibodies with heterologous flagellins did not correlate with the Lior serotype of the isolate.
摘要
采用酶联免疫吸附测定法，对患有和未患有弯曲杆菌感染的患者的肠道免疫球蛋白A（IgA）抗弯曲杆菌鞭毛蛋白抗体进行了检测。患者粪便中IgA抗鞭毛蛋白抗体水平显著高于对照组，但在29例弯曲杆菌感染患者中，仅有12例（41.4%）可检测到抗鞭毛蛋白的IgA抗体（光密度大于或等于0.100）。对10例患者粪便中IgA抗体与同源和异源纯化鞭毛蛋白进行的进一步检测显示，有1例患者具有菌株特异性。粪便IgA抗体与异源鞭毛蛋白的交叉反应性与分离株的Lior血清型无关。
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