Burr D H, Caldwell M B, Bourgeois A L, Morgan H R, Wistar R, Walker R I
Naval Medical Research Institute, Bethesda, Maryland 20814-5055.
Infect Immun. 1988 Jan;56(1):99-105. doi: 10.1128/iai.56.1.99-105.1988.
The mucosal and systemic immune responses to Campylobacter jejuni were studied in rabbits receiving gastric inoculation with live organisms. A lavage procedure was used to facilitate repeated monitoring of the intestinal immune response to C. jejuni. Immunity to C. jejuni was determined by secondary challenge by using the removable intestinal tie adult rabbit diarrhea (RITARD) model and monitoring for resistance to colonization and bacteremia. Oral-gastric inoculation of normal rabbits produced a transient intestinal colonization without diarrhea. C. jejuni serotypes differed in their ability to colonize the intestines of rabbits and to stimulate primary intestinal and serum antibody responses. Animals previously colonized were resistant to recolonization and the development of bacteremia after homologous challenge by the RITARD procedure but were not resistant to heterologous challenges. Anticampylobacter intestinal and serum IgA titers before this secondary infection were the most reliable predictors of resistance to colonization and bacteremia.
对接受空肠弯曲菌活菌胃内接种的家兔的黏膜和全身免疫反应进行了研究。采用灌洗程序以促进对空肠弯曲菌肠道免疫反应的重复监测。通过使用可移除肠段成年兔腹泻（RITARD）模型进行二次攻击并监测对定植和菌血症的抵抗力来确定对空肠弯曲菌的免疫力。正常家兔经口胃接种产生短暂的肠道定植但无腹泻。空肠弯曲菌血清型在定植家兔肠道以及刺激原发性肠道和血清抗体反应的能力方面存在差异。先前定植过的动物在通过RITARD程序进行同源攻击后对再定植和菌血症的发生具有抵抗力，但对异源攻击没有抵抗力。二次感染前的抗弯曲菌肠道和血清IgA滴度是对定植和菌血症抵抗力的最可靠预测指标。
