Bolle L, Maurer B, Janzer R C
Institute of Pathology, Division of Neuropathology, University of Lausanne, Switzerland.
Biotech Histochem. 1992 Mar;67(2):82-7. doi: 10.3109/10520299209110013.
The quantitative assessment of the age-dependent number of neuritic plaques is essential for the diagnosis of Alzheimer type dementia. This study reports the superiority of a modified Hortega-Globus stain compared to Bielschowsky and Bodian stains applied to samples obtained from ten brains of patients with a clinical history of progressive dementia. In two of ten cases only the modified Hortega-Globus stain allowed confirmation of the diagnosis of senile dementia of the Alzheimer type (SDAT). The counts of neuritic plaques in sections stained by other methods were not sufficient to establish the histological diagnosis of SDAT. These results indicate that the choice of the most sensitive staining method is critical for the correct histopathologic diagnosis of the Alzheimer type dementia.
对神经炎性斑块随年龄变化数量进行定量评估对于阿尔茨海默型痴呆的诊断至关重要。本研究报告了改良的霍特加-格洛布斯染色法相较于应用于取自十例有进行性痴呆临床病史患者大脑样本的 Bielschowsky 染色法和博迪安染色法的优越性。在十例病例中的两例中，只有改良的霍特加-格洛布斯染色法能够确诊阿尔茨海默型老年痴呆（SDAT）。用其他方法染色的切片中神经炎性斑块的计数不足以确立 SDAT 的组织学诊断。这些结果表明，选择最敏感的染色方法对于阿尔茨海默型痴呆的正确组织病理学诊断至关重要。
