Tromm A, Hüppe D, Micklefield G H, Schwegler U, May B
Department of Medicine, University Hospital, Bergmannsheil, Ruhr University of Bochum, Germany.
Gut. 1992 Sep;33(9):1289-91. doi: 10.1136/gut.33.9.1289.
An example of acute pancreatitis developing five weeks after initial treatment with 5-aminosalicylic acid (5-ASA) and methylprednisolone for severe Crohn's disease is reported in a 37 year old female patient. She had undergone cholecystectomy for gall stones some years earlier. There was no evidence of acute or chronic pancreatitis. No morphological changes of the upper gastrointestinal tract were found except for some irregularity of the main pancreatic duct and the secondary ducts on endoscopic retrograde pancreatography. Rechallenge with 5-ASA did not induce recurrent pancreatitis or changes in pancreatic enzymes. This case report supports the concept of an association between acute pancreatitis and Crohn's disease.
一名37岁女性患者报告了在最初使用5-氨基水杨酸（5-ASA）和甲泼尼龙治疗严重克罗恩病五周后发生急性胰腺炎的病例。几年前她因胆结石接受了胆囊切除术。没有急性或慢性胰腺炎的证据。除了内镜逆行胰胆管造影显示主胰管和二级胰管有一些不规则外，上消化道未发现形态学改变。再次使用5-ASA并未诱发复发性胰腺炎或胰腺酶变化。本病例报告支持急性胰腺炎与克罗恩病之间存在关联的概念。
