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患有和未患有缺血性心脏病的2型糖尿病患者的血脂控制不佳。

Poor lipid control in type-2 diabetics with and without ischemic heart disease.

作者信息

Akbar Daad H, Al-Gamdi Aish A, Hejazi Nariman A

机构信息

Department of Medicine, King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.

出版信息

Endocrine. 2003 Aug;21(3):217-20. doi: 10.1385/ENDO:21:3:217.

Abstract

To determine the frequency of type-2 diabetics who have target lipoprotein blood levels, to study these levels in patients with ischemic heart disease and cardiovascular disease risk factors, and to study the possible causes of poor control, we reviewed hyperlipdemic type-2 diabetics who were on regular follow up to the medical outpatient clinic of King Abdulaziz University Hospital from January 2000 to January 2001. A total of 202 patients were studied with mean age of 60 yr and equal male to female ratio. The mean duration of diabetes was 10 yr and it was 7 yr for hyperlipidemia. The mean level of LDL was 3.15 mmol/L and it was 1.0 mmol/L and 2.47 mmol/L for HDL and TG, respectively. Only 31% of patients had LDL < 2.6 mmol/L, 28% had HDL > 1.1 mmol/L, and 37% had TG < 1.7 mmol/L. No significant difference was found in the frequency of target level of LDL in patients with IHD and those without; 26% vs 34% (0.4). Similarly, no difference was found in those with hypertension, obesity, and patients with family history of IHD compared to those without these risk factors; 30%, 26%, 16% vs 34%, 36%, 33% (p = 0.2, 0.1, 0.4, respectively). Males were found to have a higher frequency of target LDL level compared to females; 38% vs 25% (p = 0.04). Poor diet restriction was found in 90% of patients' with poor control, lack of patients' knowledge in 62%, 70% have financial reasons, 86% of patients on multiple medications, and in 16% the treating physician took no proper action. In conclusion, a low frequency of type-2 diabetics have target levels of lipoproteins. Diabetics with IHD and CVD risk factors also have poor lipid control. Poor control was associated with poor diet compliance and use of multiple medications. Proper management and control of this disease is needed among elderly patients.

摘要

为了确定达到脂蛋白血液目标水平的2型糖尿病患者的比例,研究缺血性心脏病患者和具有心血管疾病风险因素患者的这些水平,并研究控制不佳的可能原因,我们回顾了2000年1月至2001年1月在阿卜杜勒阿齐兹国王大学医院门诊接受定期随访的高脂血症2型糖尿病患者。共研究了202例患者,平均年龄60岁,男女比例相等。糖尿病平均病程为10年,高脂血症为7年。低密度脂蛋白(LDL)平均水平为3.15 mmol/L,高密度脂蛋白(HDL)和甘油三酯(TG)分别为1.0 mmol/L和2.47 mmol/L。只有31%的患者LDL<2.6 mmol/L,28%的患者HDL>1.1 mmol/L,37%的患者TG<1.7 mmol/L。在患有缺血性心脏病(IHD)的患者和未患IHD的患者中,LDL目标水平的比例没有显著差异;分别为26%和34%(P=0.4)。同样,与没有这些风险因素的患者相比,患有高血压、肥胖症以及有IHD家族史的患者中,LDL目标水平比例也没有差异;分别为30%、26%、16%和34%、36%、33%(P值分别为0.2、0.1、0.4)。发现男性达到LDL目标水平的比例高于女性;分别为38%和25%(P=0.04)。在控制不佳的患者中,90%存在饮食限制不佳,62%患者缺乏相关知识,70%有经济原因,86%的患者使用多种药物,16%的患者治疗医生未采取适当措施。总之,达到脂蛋白目标水平的2型糖尿病患者比例较低。患有IHD和心血管疾病风险因素的糖尿病患者血脂控制也较差。控制不佳与饮食依从性差和使用多种药物有关。老年患者需要对这种疾病进行适当的管理和控制。

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