Chen Candice S, Hood Donald C, Zhang Xian, Karam Emely Z, Liebmann Jeffrey M, Ritch Robert, Thienprasiddhi Phamornsak, Greenstein Vivienne C
Department of Psychology, Columbia University, New York, New York, USA.
J Glaucoma. 2003 Oct;12(5):399-408. doi: 10.1097/00061198-200310000-00002.
To investigate the repeat reliability of the multifocal visual evoked potential (mfVEP).
Fifteen subjects with no known abnormalities of the visual system and 10 patients with glaucoma participated in the study. Monocular mfVEPs were recorded on two separate days, using a 60-sector, pattern-reversal dart board array. Within a single session, two 7-minute. recordings were obtained for each eye. The amplitude of each mfVEP response was obtained using a root mean square measure (RMS). An mfVEP ratio [10*log (RMS day 1 / RMS day 2)] provided a measure of the reproducibility of an individual response. The same calculations were performed for Run 1 compared with Run 2 within a day and Run 1 (Run 2) compared with Run 1 (Run 2) across days.
For all 1800 mfVEP responses (60 sectors x 15 subjects x 2 eyes), the correlation between the amplitude on day 2 and the amplitude on day 1 was good (r = 0.85). The mean standard deviation (SD) of the 60 mfVEP ratios for the individual subjects was 1.63 dB for the 14-minute records (the combination of the two 7-minute recordings). On average for the 7-minute records, the mean SD across days was 1.77 dB while the mean SD within a day was 1.53 dB. The correlation within a day (r = 0.87) also was slightly larger than across days (r = 0.80). The mean SD decreased as the RMS amplitude increased. The patients' mean SD was 1.75 dB with r equal to 0.82.
The repeat reliability of the mfVEP was good (approximately 1.6dB); in fact, it was better than that typically obtained with static automated perimetry (approximately 2.7dB). Repeat testing on separate days added surprisingly little to the variability seen with repeat testing within the same session.
研究多焦视觉诱发电位（mfVEP）的重复可靠性。
15名视觉系统无已知异常的受试者和10名青光眼患者参与了本研究。使用60扇区、模式反转飞镖靶阵列在两个不同日期记录单眼mfVEP。在单个测试环节中，每只眼睛进行两次7分钟的记录。使用均方根测量（RMS）获得每个mfVEP反应的振幅。mfVEP比率[10×log（第一天RMS/第二天RMS）]提供了个体反应可重复性的度量。对同一天内的第一次测试与第二次测试以及不同日期的第一次测试（第二次测试）与第一次测试（第二次测试）进行相同的计算。
对于所有1800个mfVEP反应（60个扇区×15名受试者×2只眼睛），第二天的振幅与第一天的振幅之间相关性良好（r = 0.85）。14分钟记录（两次7分钟记录的组合）中，个体受试者60个mfVEP比率的平均标准差（SD）为1.63 dB。7分钟记录平均而言，不同日期的平均SD为1.77 dB，而同一天内的平均SD为1.53 dB。同一天内的相关性（r = 0.87）也略大于不同日期之间的相关性（r = 0.80）。平均SD随着RMS振幅的增加而降低。患者的平均SD为1.75 dB，r等于0.82。
mfVEP的重复可靠性良好（约1.6dB）；实际上，它优于静态自动视野计通常获得的结果（约2.7dB）。在不同日期进行重复测试，与在同一测试环节内进行重复测试相比，增加的变异性出奇地小。
