用类志贺邻单胞菌（SVC 01）免疫家兔预防宋内志贺菌感染。
Protection from Shigella sonnei infection by immunisation of rabbits with Plesiomonas shigelloides (SVC 01).
作者信息
Sayeed S, Sack D A, Qadri F
机构信息
Department of Microbiology, University of Dhaka, Bangladesh.
出版信息
J Med Microbiol. 1992 Dec;37(6):382-4. doi: 10.1099/00222615-37-6-382.
Plesiomonas shigelloides, an organism commonly found in water, is only rarely associated with diarrhoea in man. P. shigelloides serotype O:17 (SVC O1), which is antigenically similar to Shigella sonnei, was found to be neither virulent nor toxic for rabbits. Rabbits immunised by feeding with P. shigelloides (SVC O1) were completely protected against an oral challenge with 10(10) cells of S. sonnei but non-immunised rabbits were not. P. shigelloides (SVC O1) may be a useful vaccine strain for shigellosis.
类志贺邻单胞菌是一种常见于水中的微生物，在人类中很少引起腹泻。类志贺邻单胞菌O:17血清型（SVC O1），其抗原性与宋内志贺菌相似，被发现对兔子既无致病性也无毒性。通过喂食类志贺邻单胞菌（SVC O1）免疫的兔子，可完全抵御10¹⁰个宋内志贺菌细胞的口服攻击，但未免疫的兔子则不能。类志贺邻单胞菌（SVC O1）可能是一种用于志贺菌病的有用疫苗株。
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