Mao Chuanbin, Solis Daniel J, Reiss Brian D, Kottmann Stephen T, Sweeney Rozamond Y, Hayhurst Andrew, Georgiou George, Iverson Brent, Belcher Angela M
Departments of Chemistry and Biochemistry, University of Texas (UT) at Austin, Austin, TX 78712, USA.
Science. 2004 Jan 9;303(5655):213-7. doi: 10.1126/science.1092740.
We report a virus-based scaffold for the synthesis of single-crystal ZnS, CdS, and freestanding chemically ordered CoPt and FePt nanowires, with the means of modifying substrate specificity through standard biological methods. Peptides (selected through an evolutionary screening process) that exhibit control of composition, size, and phase during nanoparticle nucleation have been expressed on the highly ordered filamentous capsid of the M13 bacteriophage. The incorporation of specific, nucleating peptides into the generic scaffold of the M13 coat structure provides a viable template for the directed synthesis of semiconducting and magnetic materials. Removal of the viral template by means of annealing promoted oriented aggregation-based crystal growth, forming individual crystalline nanowires. The unique ability to interchange substrate-specific peptides into the linear self-assembled filamentous construct of the M13 virus introduces a material tunability that has not been seen in previous synthetic routes. Therefore, this system provides a genetic toolkit for growing and organizing nanowires from semiconducting and magnetic materials.
我们报道了一种基于病毒的支架，用于合成单晶硫化锌、硫化镉以及独立的化学有序钴铂和铁铂纳米线，其通过标准生物学方法改变底物特异性。在M13噬菌体的高度有序丝状衣壳上表达了在纳米颗粒成核过程中表现出对组成、尺寸和相控制的肽（通过进化筛选过程选择）。将特定的成核肽掺入M13衣壳结构的通用支架中，为定向合成半导体和磁性材料提供了一个可行的模板。通过退火去除病毒模板促进了基于定向聚集的晶体生长，形成了单个晶体纳米线。将底物特异性肽互换到M13病毒的线性自组装丝状结构中的独特能力引入了一种在以前的合成路线中未见的材料可调性。因此，该系统为从半导体和磁性材料生长和组织纳米线提供了一个遗传工具包。
