Morton A R, Fitch K D
Department of Human Movement Studies, University of Western Australia, Nedlands, Perth.
Sports Med. 1992 Oct;14(4):228-42. doi: 10.2165/00007256-199214040-00002.
Almost all asthmatics are prone to asthma triggered by moderate to severe exercise. Fortunately there are a number of pharmaceutical agents now available which can prevent and/or reverse exercise-induced asthma (EIA) and allow many asthmatics to participate in vigorous physical activities with minimum respiratory disadvantage. Regular exercise is an accepted part of the management of asthma and EIA can now be controlled so successfully that a number of elite sportspersons, in almost all types of sporting events, are asthmatic. This control of EIA, which is essential if asthmatics are to participate safely, requires that the patient and his/her doctor initiate a strategy to manage the disease during sport and other physical activities. In recent years the mortality and morbidity from asthma have been increasing and this has indicated the need to improve patient care. One of the most important innovations aiming to improve the control and treatment of asthma has been the recent development of the 6 point asthma management plan which is a strategy to simplify and optimise the long term management of asthma. It aims to improve the quality of life of most asthmatics and more importantly, prevent deaths due to asthma. Because antidoping controls operate in many high performance sports it is essential that the EIA management plan rely on those medications which are permitted. The list of allowable drugs is in continual flux as new ones are added and others are challenged on the grounds of possible ergogenicity. All aerosol beta 2-agonists except fenoterol, the khellin derivatives, theophylline, ipratropium bromide and the aerosol corticosteroids are currently permitted. Some nonasthmatic athletes who are aware of the improved performance of asthmatic athletes when using pre-exercise medication have been known to take antiasthma medication in the hope that it might improve their performance. Current evidence indicates, however, that the permitted medications are not ergogenic and do not give the asthmatic any advantage over the nonasthmatic athlete but merely removes the respiratory disadvantage under which he/she competes.
几乎所有哮喘患者都容易因中度至重度运动引发哮喘。幸运的是,现在有多种药物可供使用,它们能够预防和/或逆转运动诱发的哮喘(EIA),使许多哮喘患者能够以最小的呼吸功能劣势参与剧烈体育活动。规律运动是哮喘管理公认的一部分,如今EIA能够得到如此成功的控制,以至于在几乎所有类型的体育赛事中,都有一些精英运动员患有哮喘。要让哮喘患者安全参与运动,对EIA的这种控制至关重要,这就要求患者及其医生制定一项在运动和其他体育活动期间管理该疾病的策略。近年来,哮喘的死亡率和发病率一直在上升,这表明需要改善患者护理。旨在改善哮喘控制和治疗的最重要创新之一是最近制定的六点哮喘管理计划,这是一种简化和优化哮喘长期管理的策略。其目的是提高大多数哮喘患者的生活质量,更重要的是,预防哮喘导致的死亡。由于在许多高水平运动中都实施反兴奋剂控制,因此EIA管理计划必须依赖那些被允许使用的药物,这一点至关重要。随着新药物的添加以及其他药物因可能具有增强体能作用而受到质疑,允许使用的药物清单一直在不断变化。目前允许使用的药物包括除非诺特罗之外的所有气雾剂β2激动剂、凯林衍生物、茶碱、异丙托溴铵和气雾剂皮质类固醇。已知一些非哮喘运动员在了解到哮喘运动员在使用运动前药物时表现有所改善后,会服用抗哮喘药物,希望借此提高自己的成绩。然而,目前的证据表明,允许使用的药物并无增强体能的作用,也不会让哮喘运动员比非哮喘运动员具有任何优势,而只是消除了他们在比赛中面临的呼吸功能劣势。