Jones P M, George A M
Department of Cell and Molecular Biology, University of Technology Sydney, Broadway, NSW, Australia.
Cell Mol Life Sci. 2004 Mar;61(6):682-99. doi: 10.1007/s00018-003-3336-9.
ATP-binding cassette (ABC) transporters are multidomain integral membrane proteins that utilise the energy of ATP hydrolysis to translocate solutes across cellular membranes in all phyla. ABC transporters form one of the largest of all protein families and are central to many important biomedical phenomena, including resistance of cancers and pathogenic microbes to drugs. Elucidation of the structure and mechanism of ABC transporters is essential to the rational design of agents to control their function. While a wealth of high-resolution structures of ABC proteins have been produced in recent years, many fundamental questions regarding the protein's mechanism remain unanswered. In this review, we examine the recent structural data concerning ABC transporters and related proteins in the light of other experimental and theoretical data, and discuss these data in relation to current ideas concerning the transporters' molecular mechanism.
ATP结合盒（ABC）转运蛋白是多结构域整合膜蛋白，利用ATP水解产生的能量在所有生物门类中跨细胞膜转运溶质。ABC转运蛋白构成了所有蛋白质家族中最大的家族之一，并且是许多重要生物医学现象的核心，包括癌症和致病微生物对药物的抗性。阐明ABC转运蛋白的结构和机制对于合理设计控制其功能的药物至关重要。虽然近年来已经产生了大量ABC蛋白的高分辨率结构，但关于该蛋白质机制的许多基本问题仍未得到解答。在这篇综述中，我们根据其他实验和理论数据审视了有关ABC转运蛋白及相关蛋白的最新结构数据，并结合当前关于转运蛋白分子机制的观点讨论了这些数据。
