Tan H W, Ty A, Goh S G N, Wong M C, Hong A, Chuah K L
Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.
J Clin Pathol. 2004 Aug;57(8):882-4. doi: 10.1136/jcp.2004.016659.
Intracranial germ cell tumours are rare. The incidence of primary intracranial yolk sac tumour is even more uncommon, with only two reported cases being associated with Down's syndrome in the English literature. This report details the findings of yolk sac tumour in the pineal region affecting a 22 year old Chinese man with Down's syndrome. Histology revealed yolk sac tumour with only a solid pattern, potentially mimicking the more common germinoma in the pineal region. No other germ cell components were identified. This is the third report of intracranial yolk sac tumour manifesting in a patient with trisomy 21. The pathology of this tumour and its differential diagnoses are discussed.
颅内生殖细胞肿瘤较为罕见。原发性颅内卵黄囊瘤的发病率更为罕见，英文文献中仅有两例报告与唐氏综合征相关。本报告详细介绍了一名患有唐氏综合征的22岁中国男性松果体区卵黄囊瘤的检查结果。组织学检查显示为仅具有实性结构的卵黄囊瘤，可能会与松果体区更常见的生殖细胞瘤相混淆。未发现其他生殖细胞成分。这是第三例21三体综合征患者出现颅内卵黄囊瘤的报告。本文讨论了该肿瘤的病理及其鉴别诊断。
