一种来自日本香茶菜的新型细胞毒性氧杂环丁烷对映贝壳杉烷型二萜。

A novel cytotoxic oxetane ent-kauranoid from Isodon japonicus.

作者信息

Han Quanbin, Zhang Jixia, Lu Yang, Wu Yunshan, Zheng Qitai, Sun Handong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, P. R. China.

出版信息

Planta Med. 2004 Jun;70(6):581-4. doi: 10.1055/s-2004-827165.

DOI:10.1055/s-2004-827165

PMID:15318402

Abstract

A novel ll,20: 1,20-diepoxy-ent-kaurane diterpenoid, maoyecrystal 1 (1), was isolated from Isodan japonicus, and its structure was elucidated by spectroscopic methods and comparison with another new ent-kauranoid, rubescensin W (2) from Isodon rubescens var. taihangensis. The structure of 2 was determined by single crystal X-ray diffraction analysis. A bioassay of their cytotoxity against K562 cells showed that the oxetane group of 1 might be a bioactive moiety.

摘要

从毛叶香茶菜中分离出一种新型的1,20:1,20 - 二环氧 - 对映 - 贝壳杉烷二萜类化合物——毛叶结晶1（1），通过光谱方法并与另一种来自太行变种香茶菜的新对映 - 贝壳杉烷类化合物——冬凌草素W（2）进行比较，阐明了其结构。2的结构通过单晶X射线衍射分析确定。对它们针对K562细胞的细胞毒性进行的生物测定表明，1的氧杂环丁烷基团可能是一个生物活性部分。