Netea Mihai G, Gijzen Karlijn, Coolen Neeltje, Verschueren Ineke, Figdor Carl, Van der Meer Jos W M, Torensma Ruurd, Kullberg Bart Jan
Department of Medicine, University Medical Center St. Radboud, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Microbes Infect. 2004 Sep;6(11):985-9. doi: 10.1016/j.micinf.2004.05.013.
Dendritic cells (DC) function as professional phagocytes to kill Candida albicans and subsequently present it to the adaptive immune system. Monocytes, macrophages and DC were generated from five individual donors and their Candida-killing capacity and cytokine release were assessed. Compared to monocytes and macrophages, DC from healthy volunteers were significantly less effective in C. albicans--stimulated cytokine release, killing of C. albicans blastoconidia and damaging of C. albicans hyphae. In conclusion, while important as antigen-presenting cells and initiators of the adaptive immune system, DC are poor in both intracellular killing and damaging of C. albicans hyphae. Effective handling of large numbers of C. albicans is the prime task of the innate immune system consisting of large numbers of neutrophils and monocytes.
树突状细胞（DC）作为专职吞噬细胞发挥作用，杀死白色念珠菌，随后将其呈递给适应性免疫系统。从五名个体供体中生成单核细胞、巨噬细胞和DC，并评估它们的杀念珠菌能力和细胞因子释放情况。与单核细胞和巨噬细胞相比，来自健康志愿者的DC在白色念珠菌刺激的细胞因子释放、白色念珠菌芽生孢子的杀伤以及白色念珠菌菌丝的损伤方面效果明显较差。总之，虽然DC作为抗原呈递细胞和适应性免疫系统的启动者很重要，但它们在细胞内杀伤和损伤白色念珠菌菌丝方面表现不佳。有效处理大量白色念珠菌是由大量中性粒细胞和单核细胞组成的固有免疫系统的首要任务。
